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Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
Reliably identify senescence signaling in your samples using biomarkers with a 3-stage approach outlined in this video. No single assay is sufficient, but screening, co-staining, and verification with multiple biomarkers can improve your confidence.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Senescence is a cellular state during which cells remain metabolically active, but irreversibly withdraw from the cell cycle and fail to respond to proliferation-inducing stimuli.
Senescence has been linked to a general decline in tissue function during aging as well as a number of disease states.
Senescent cells increase in number during aging and have been implicated in the decline of organismal function over time, as well as in the progression of age-related diseases.
Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
p16 is an important cervical cancer biomarker but studies have shown variable expression levels, suggesting an IHC-validated p16 INK4A antibody is needed.
Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
This webinar explores the impact of senescence on age-related dysfunction and chronic disease and introduces potential therapies targeting senescent cells.
Find Pathways and Diagrams By Disease Area
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Neurodegenerative diseases are characterized by loss of neuronal structure & function that leads to problems with movement ataxia & mental function & dementia.
Cell Signaling Technology pathways by research area
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Overview of Cellular Metabolism pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
Cell viability assays measure the population of live, viable cells within a sample. Typically, viability assays measure markers of cell health, including cellular metabolism, ATP levels, and cell proliferation.
A table that lists shelf-life expectations for CST products (when stored under the recommended conditions).
CST Technical Support Article
CST has not tested this kit successfully on tissue sections (frozen or paraffin-embedded), so we do not have a tissue-specific protocol to provide. At one time we tried using this kit on paraffin-embedded (FFPE) tissue slides, but unfortunately, we did not obtain good results. We have, however, spoken with customers who use this kit on frozen tissue and there are several publications that have successfully used this kit under these conditions. We have listed a few of them below for reference.B. G. Childs, T. J. Bussian, D. J. Baker (2019) Cellular Identification and Quantification of Senescence-Associated Beta-Galactosidase Activity in Vivo Methods Mol Biol. 1896: 31-38.Baker, D. J. et al. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat. Genetics 36, 744-749.Swarbrick, A. et al. (2008) Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proc Natl Acad Sci U S A…
We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.