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Interactive p38 MAPK pathway. Learn how p38 MAPK is involved in regulation of HSP27, MAPKAPK-2, MAPKAPK-3, & several transcription factors.
Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Learn more about commonly used chemical modulators to study cellular physiology and biology.
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
As a new antibody is developed, Cell Signaling Technology scientists test the antibody’s stability and activity
Cell Signaling Technology pathways by research area
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
Identifies and quantifies up to many hundreds of critical signaling nodes across pathways involved in cancer biology, immune cell signaling, and more.
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
A demonstration of the perils of deviating from Cell Signaling Technology's recommended protocols.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
A list of antibodies directed against chaperones and other proteins involved in Protein Folding offered by Cell Signaling Technology.
Discover the TGF Beta signaling pathway and impact on cell growth & tissue homeostasis. Learn here the mechanisms behind this vital signaling cascade.
Phospho-Erk product lists, product citation lists, product selection tools, comparison tables and educational resources for MAPK signaling from Cell Signaling Technology.
Expert-reviewed interactive pathway providing a current overview of TLR signaling.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
Case Study 4: Exceptional Performance of XP Monoclonal Antibodies from Cell Signaling Technology.
Understanding how TLR signaling is activated by molecular patterns is relevant not only to their role in combating infection but also in cancer.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
We apologize for any confusion regarding our EGF Receptor (D38B1) XP® Rabbit mAb #4267 and its recommendation for IHC on human tissue only. The species reactivity at the top of the web page is determined by western blot. We have tested this clone on mouse tissue by IHC and found that it does not work very well despite being an excellent tool for the analysis of human tissue. For this reason, we added a note to the product's web page and datasheet under Sensitivity/Specificity indicating that for IHC and IF the species reactivity is human only. We would instead suggest our EGF Receptor (D1P9C) Rabbit mAb (Mouse Preferred) #71655 for use with mouse tissues.
Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.