Resources results for "bcl-2"

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BH1-4 Protein Domains

A scientific resource for the BH protein domains containing information on structure, function, and domain binding in apoptosis.

Mitochondrial Control of Apoptosis

Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.

Cell Death

Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.

Inhibition of Apoptosis

Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.

PTMScan® Direct Apoptosis & Autophagy

Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.

Antibody Validation for Western Blotting

The accuracy of western blot results relies heavily on the quality of the primary antibody used. CST™ antibodies are validated using multiple experiments.

Therapeutic Approaches for the Treatment of Multiple Myeloma

Recent advancements including next-generation proteasome inhibitors, monoclonal bispecific antibodies, antibody-drug conjugates, and CAR-T therapies that have changed the therapeutic landscape for multiple myeloma.

The Role of Cell Death in Viral Infection

Regulation of cell death due to viral infection is important for host survival. In this series, we look at pathways regulated through cellular responses to viruses.

Cell Death and Viability

Products and Related Resources for Cell Death and Viability SARS-CoV-2 Research

Mechanisms of Cell Death: Apoptosis

Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.

Cell Death and Disease

Death Receptor Signaling

Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.

Resources

The Bcl-xL (54H6) Rabbit mAb #2764 recognizes a portion of the human Bcl-xL sequence which is retained in all three isoforms of Bcl-xL. Please see UniProt for the precise isoform sequences:

https://www.uniprot.org/uniprot/Q07817#sequences

The doublet is most likely Bcl-xL and Bcl-xB, as Bcl-xS has a lower predicted molecular weight (19 kDa versus 25-26 kDa).

Cell Process: What signaling pathways are associated with cellular senescence?

Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.

Cell Process: Seven Assays to Detect Apoptosis

Apoptosis is a highly regulated form of programmed cell death that occurs in multicellular organisms throughout life and in response to cellular stress.

Tools for Monitoring Cell State

Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.

Novel Therapeutic Approaches for Diffuse Large B-Cell Lymphoma

Lymphoma is a cancer of the lymphatic system, a key part of the body’s immune system. Treatment options & patient prognoses differ based on lymphoma type.

Autophagy Signaling

Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.

Protein and Pathway Abbreviations

Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.

Solutions for Targeted Protein Degradation

Streamline Targeted Protein Degradation Drug Discovery with specific, application-validated antibodies and industry-leading proteomic services.

Hallmarks of Cancer: Evading Growth Suppressors

Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Apoptosis.

BTB/POZ Protein Domain

A scientific resource for the BTB/POZ protein domain containing information on structure, function, and domain binding during chromatin remodeling.

Solutions for Oncology Therapeutics Discovery

Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.

Hallmarks of Cancer: Resisting Cell Death

Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.