Neurodegenerative diseases are characterized by a loss of neuronal structure and function that leads to problems with movement (ataxis) or mental function (dementia). These changes occur due to genetic mutations or protein folding disorders that can accumulate with age. While pathophysiologies like amyloid plaques are well documented, many of the cellular processes that drive neurodegeneration have yet to be fully elucidated. Defects in these key processes may be shared among different neurogenerative diseases, making it likely that new therapies targeting one process may alleviate the progression of many conditions.
We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease. Wondering how to identify the many different cell types that make up the central nervous system (CNS)? We also have a Cell Type Marker Guide!