Render Target: SSR
Render Timestamp: 2025-03-06T17:12:21.129Z
Commit: 9fc0f116116d9da247dc8ddd4e5fe811153412e1
XML generation date: 2025-03-04 23:01:11.506
Product last modified at: 2025-03-06T09:00:34.000Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Apolipoprotein C-I (F9L6S) Rabbit mAb #92796

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 9
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Apolipoprotein C-I (F9L6S) Rabbit mAb recognizes endogenous levels of total apolipoprotein C-I protein. This antibody detects a 35 kDa and a 45 kDa protein of unknown identity in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human apolipoprotein C-I protein.

    Background

    Apolipoprotein C-I (ApoC1) is a member of the apolipoprotein family, which takes part in the assembly of supramolecular lipoprotein complexes (1-3). The APOC1 gene is expressed in many tissues, with the highest expression in liver and differentiated macrophages (1-3). ApoC1 protein is synthesized as an 83 amino acid precursor, which is cleaved into a 57 amino acid mature protein, making it the smallest of all circulating apolipoproteins (1). ApoC1 is involved in the metabolism of triglyceride-rich lipoproteins by inhibiting the binding of very low density lipoproteins (VLDL) (4,5). ApoC1 is the main physiological inhibitor of the cholesterol ester transfer protein (CETP), which is associated with macrovascular complications in patients with type 1 diabetes (T1D) (6).
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