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6/7/2026, 11:55:11 PM UTC
Commit: 33ae406c5df2bbc7a7d3c17605228fbeff8ea416
XML generation date: 2026-06-05 17:23:30.617
Product last modified at: 2026-01-29T08:01:43.931Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

G-beta-L (86B8) Rabbit Monoclonal Antibody (Magnetic Bead Conjugate) #6938

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Inquiry Info. # 6938

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    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 37
    Source/Isotype Rabbit IgG
    Application Key:
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Description

    This Cell Signaling Technology (CST) antibody is immobilized by the covalent reaction of hydrazinonicotinamide-modifed antibody with formylbenzamide-modified magnetic bead. GβL (86B8) Rabbit mAb (Magnetic Bead Conjugate) is useful for immunoprecipitation assays of GβL protein. The unconjugated GβL (86B8) Rabbit mAb #3274 reacts with human, mouse, rat, and monkey GβL protein. CST expects that GβL (86B8) Rabbit mAb (Magnetic Bead Conjugate) will also recognize GβL in these species.
    MW (kDa) 37

    Product Usage Information

    Application Dilution
    Immunoprecipitation 1:20

    Storage

    Supplied in PBS Buffer (pH 7.2), 0.1% Tween® 20. Store at 4°C. Do not aliquot the antibodies.

    プロトコール

    Specificity / Sensitivity

    G-beta-L (86B8) Rabbit Monoclonal Antibody (Magnetic Bead Conjugate) detects endogenous levels of total GβL protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    GβL (86B8) Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln210 of human GβL.

    Background

    Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor (1). GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1 (2).

    Alternate Names

    G protein beta subunit like; G protein beta subunit-like; Gable; GbetaL; GBL; LST8; Mammalian lethal with SEC13 protein 8; MGC111011; MLST8; MTOR associated protein, LST8 homolog; MTOR associated protein, LST8 homolog (S. cerevisiae); POP3; Protein GbetaL; Target of rapamycin complex subunit LST8; TORC subunit LST8; WAT1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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