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PTMScan® Direct Cell Cycle & DNA Damage

PTMScan® Direct Cell Cycle and DNA Damageサービスでは、創薬、バイオマーカーの探索、診断法の開発で重要なタンパク質の修飾部位やシグナルの分岐点を、細胞周期制御やDNA損傷経路およびその関連タンパク質に標的を絞ってスクリーニング、定量を行います。下の表は、PTMScan® Direct Cell Cycle and DNA Damageサービスでモニター可能なタンパク質修飾部位の一覧です。

PTMScan® Direct Cell Cycle and DNA Damageサービスは、168種のタンパク質の固有のリン酸化部位263サイトを同定し、定量的にプロファイリングする安定した方法です。

PTMScan Direct細胞周期&DNA損傷経路の解析範囲

Cell Cycle and DNA Damageでモニター可能なタンパク質修飾部位
Cell Cycle and DNA Damageでモニター可能なタンパク質修飾部位
53BP1 53BP1 (Ser265) α-tubulin APE1
ATM ATM (Ser1981) ATM (Ser1983) ATR
ATR (Ser428) ATRIP AurA (Thr287) AurA (Thr288)
AurA (Thr292) AurB AurB (Thr232) AurB (Thr236)
AurB (Tyr239) AurC (Thr198) AurC (Thr202) AurC (Tyr205)
β-Actin BLM BLM (Ser74) BRCA2 (Thr77)
Bub3 Bub3 (Ser135) Bub3 (Thr133) CBP
CCND1 (Thr286) CCND1 (Thr288) CCNE1 CCNK iso3
CCNL1 (Ser372) CCNL1 (Ser374) CCNL1 (Tyr376) CCNT1 (Ser626)
CCNYL1 CDC123 Cdc16 Cdc23
Cdc25B Cdc25C Cdc25C (Ser191) Cdc25C (Ser198)
Cdc27 Cdc37 Cdc42 CDC45L
CDCA7 (Thr213) CDK1 CDK1 (Thr14) CDK1 (Tyr15)
CDK1 (Tyr19) CDK10 CDK11 CDK2
CDK2 (Thr14) CDK2 (Tyr15) CDK3 CDK3 (Thr14)
CDK3 (Tyr15) CDK4 CDK5 (Tyr15) CDK6
CDK7 CDK8 CHED (Ser1054) CHED (Ser1065)
CHED (Ser1066) CHED (Thr1056) CHED (Thr1058) Chk1
Chk1 (Ser296) Chk1 (Ser307) Chk1 (Ser308) Chk1 (Ser315)
Chk1 (Ser316) Chk1 (Ser317) Chk1 (Ser345) Chk1 (Ser357)
Chk1 (Thr348) Chk1 (Tyr314) Chk2 Chk2 (Ser379)
DDB1 DNA-PK DNA-PK (Ser3205) ERK1
ERK1 (Thr202) ERK1 (Tyr204) ERK2 ERK2 (Thr185)
ERK2 (Tyr187) ERK5 (Thr219) ERK5 (Tyr221) FANCB
FANCD2 FANCI GAPDH H2AX
H2AX (Ser140) H2AX (Thr137) H3 JNK1 (Thr183)
JNK1 (Tyr185) JNK2 (Thr183) JNK2 (Thr188) JNK2 (Tyr185)
JNK3 (Thr221) JNK3 (Tyr223) Ku70 Ku80
LOC651610 LOC731751 (Ser3204) MCM2 MCM3
MCM4 MCM5 MCM6 MCM7
MKK3 (Ser253) MKK4 (Ser257) MLH1 MRE11A
MSH2 (Ser717) MSH6 (Ser309) MST1 (Ser40) MST1 (Ser43)
Myt1 (Ser40) NBS1 NPM1 (Ser125) NUCKS
NUCKS (Ser14) NUCKS (Ser181) NUCKS (Ser19) NuMA-1
NuMA-1 (Ser1772) NuMA-1 (Ser395) NuMA-1 (Thr1776) p300
p21Cip1 p21Cip1 (Ser130) p27Kip1 p27Kip1 (Ser175)
p27Kip1 (Ser178) p27Kip1 (Ser183) p27Kip1 (Thr170) p27Kip1 (Thr187)
p38α (Ser61) p38α (Thr175) p38α (Thr180) p38α (Tyr182)
p38δ (Thr180) p38δ (Tyr182) p38γ (Ser180) p38γ (Thr183)
p38γ (Tyr185) p53 (Ser392) p70S6K (Ser243) p70S6K (Thr248)
p70S6K (Thr250) p70S6K (Thr252) p70S6K (Thr256) p70S6Kb (Ser219)
p70S6Kb (Ser356) p70S6Kb (Thr226) p70S6Kb (Thr228) p70S6Kb (Thr232)
p90RSK p90RSK (Ser221) p90RSK (Thr225) p90RSK (Tyr220)
PARP1 (Ser179) PCNA PCTAIRE1 (Tyr176) PCTAIRE2 (Tyr203)
PITSLRE (Tyr449) PITSLRE B (Tyr437) PMS2 (Ser425) POLA
POLD1 POLD2 PRC1 (Ser500) PRC1 (Ser501)
PRC1 (Ser513) PRC1 (Ser516) PRC1 (Thr509) PRC1 (Tyr511)
Profilin-1 Profilin-2 Rad17 RAD21
RAD21L1 RAD23A RAD23B RAD54B
RAD54B (Ser867) RAD54B (Ser869) Rb Rb (Ser773)
Rb (Ser780) Rb (Ser788) Rb (Ser794) Rb (Ser795)
Rb (Ser807) Rb (Ser811) Rb (Ser816) Rb (Thr774)
Rb (Thr778) Rb (Thr821) Rb (Thr823) Rb (Thr826)
Rb (Tyr790) Rb (Tyr805) Rb (Tyr813) RBBP4
RBBP7 RCC1 RFA2 RFC1 (Ser923)
RFC2 RFC3 RFC4 RFC5
RhoQ RPA1 RPA3 RRas
RSK2 RSK2 (Ser227) RSK2 (Thr231) RSK2 (Tyr226)
RSK3 RSK4 RSK4 (Ser232) RSK4 (Thr236)
RSK4 (Tyr231) Smad5 (Ser57) Smad5 (Ser58) Smc5
Smc5 (Ser792) Smc5 (Ser793) SMG1 (Ser111) SMG1 (Ser121)
SMG1L (Ser111) SMG1L (Ser121) tau (Ser713) tau (Ser717)
tau (Ser721) tau (Thr720) tau (Tyr711) TOP2A
TOP2B TOPBP1 XPG (Ser324) XPG (Ser697)
XPG (Ser699) XRCC1 XRCC1 (Ser241) ZNF828 (Ser405)
ZNF828 (Ser505) ZNF828 (Ser507) ZNF828 (Thr403)  
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