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Cytokine Receptor Complexes and Activation

3D animated video tutorial illustrating IL-6 eceptor complex formation and activation.

Jak and Cytokine Receptor Mutants in Cancer Table (Table Resources)

Jak and cytokine receptor mutations found in various cancers, along with the corresponding PubMed reference(s).

Jak/Stat Utilization Table (Table Resources)

The Jak/Stat Utilization Table displays the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.

Angiogenesis Resources (Pathway Diagram)

Overview of Angiogenesis antibodies & related reagents, interactive pathway diagrams, and other technical resources.

CST CUT&RUN Kit: Validated for Flexibility

Learn how we have validated and optimized our CUT&RUN Kit to yield better signal-to-noise ratios, require fewer cells to analyze protein-DNA interactions, and be compatible with tissue samples. Get up to speed on all the protocol improvements we have mad

Overview of Metabolism and Metabolic Disorders

Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.

Neuroinflammation in Neurodegenerative Diseases

Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer's disease, Parkinson's

Immuno-Parallel Reaction Monitoring (iPRM) (Proteomics Overviews)

iPRM is a multiplexed LC/MS assay service that combines the specificity of mass spectrometry, the throughput of an immunoassay, and the power of multiplexing to accelerate the time-to-market of your drug and/or diagnostic test.

TIR Protein Domain (Protein Domains)

A scientific resource for the TIR protein domain containing information on structure, function, and binding in TLR Signaling.

Types of ELISA (Enzyme-linked Immunosorbent Assay) Tests

Several types of ELISAs have been developed: direct ELISA, indirect ELISA, sandwich ELISA, competitive ELISA, multiplex ELISA. The types of ELISAs are categorized based on the type of antibodies and enzymes used to bind the antigen of interest.

Synopsis of Cell Proliferation, Metabolic Status, and Cell Death

Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.

Product Shelf-Life (Product Shelflife Table)

A table that lists shelf-life expectations for CST products (when stored under the recommended conditions).

Cellular Senescence

Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.

MAP Kinase Signaling Resources (Pathway Diagram)

Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.

Understanding Neurodegenerative (NDG) Diseases

Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.

Immunology/Inflammation (Pathway Diagram)

Expert-reviewed interactive pathways providing current overviews of NF-kB and Toll-like Receptor (TLR) signaling, as well as links to products from Cell Signaling Technology.

PI3K/AKT/MAPK Signaling (Pathway Diagram)

Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.

Ubiquitin Ligase Table (Table Resources)

The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).

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