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がん

がん

がんは複雑で不均一な疾患であり、遺伝的変化やエピジェネティクス変化によって、正常な細胞機能が損なわれることで発生します。がんのメカニズムをより良く理解するために、Hanahan博士とWeinberg博士は、下記のような11のがんの特性と、2つのイネーブリング特性をリスト化しました。self-sufficiency in growth signals, insensitivity to anti-growth signals, evading apoptosis, limitless replicative potential, sustained angiogenesis, tissue invasion and metastasis, reprogramming energy metabolism and evading immune response, and the two enabling traits: ゲノムの不安定性と変異、そして腫瘍促進性の炎症)。Cell Signaling Technology (CST) には、新規治療法の開発からがんの病態に関する新たなインサイトの発見まで、多様でダイナミックながん研究のニーズをサポートするために、非常に信頼性が高く、感度が高い、検証済みの幅広い製品カタログを基盤とする、極めて重要な専門知識があります。

がんの特性

The 11 hallmarks of cancer as described by Hanahan and Weinberg provide an organizational structure for understanding cancer cell genotypes and assisting in development of novel therapeutics. CST offers the tools to interrogate these hallmarks through a comprehensive catalog of reliable and validated antibodies that target the following mechanisms: sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, enabling replicative immortality, tumor promoting inflammation, activating invasion and metastasis, inducing angiogenesis, genome instability and mutation, and resisting cell death.

がん研究アッセイとコントロール

Cell-based assays in cancer research are important tools for probing signaling pathways involved in tumorigenesis and metastasis. CST offers a variety of assays and kits that aid in the characterization of important cancer mechanisms and cellular pathways including: ALK and ROS1, caspase-3 activity, epigenetic biomarkers, and regulators and histone modifications for across a range of cancer types.

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