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発生生物学と幹細胞

発生生物学と幹細胞

発生生物学の研究では、胚発生期の組織の成長や形成、組織の維持や創傷治癒に関与する幹細胞が注目を集めています。これらのメカニズムは、Wnt、Hedgehog、Hippo、Notch、TGF-βなどのシグナル伝達経路が協調することよって制御されています。これらの制御が破綻すると、がんの発生、増殖、転移の原因になることがあります。がん幹細胞 (CSC) は、腫瘍の発生、細胞増殖、転移、化学療法や放射線療法に対する抵抗性などに関与していると考えられています。CSCを研究することで、がんのメカニズムを解明し、新しい治療法を開発することができるかもしれません。Cell Signaling Technology (CST) は、正常な発生、がんの進行、その他の変性疾患などの根底にある発生シグナル伝達経路や基本的なメカニズムを解明するための検証済みの製品を幅広く取り揃えています。

発生生物学シグナル伝達

Development and cellular activities are regulated by a dynamic and intricate network of pathways and mechanisms coordinated through cell signaling, such as, the TGF-, Hippo, and Wnt/-catenin pathways. CST has a comprehensive selection of products to elucidate the signaling pathways responsible for the development of complex physiological systems and cancer pathogenesis.

転写因子

Transcription factors are responsible for regulating gene expression, thereby affecting regulation and differentiation of stem cells, development, and tissue formation. Our diverse catalog of antibodies will enable the understanding of transcription factor activity and their role in regulating cellular development.

幹細胞と分化マーカー

Understanding cell differentiation processes, in addition to the regulation of stem cell pluripotency and self-renewal, is important for understanding developmental disorders, and other related diseases, such as cancer and diabetes. CST offers a diverse catalog of products to detect and visualize specific markers of stem cell populations and verify differentiation status through techniques such as immunocytochemistry.

多能性と分化のエピジェネティック制御

By activating or repressing gene expression, epigenetic modifications are important to maintain the pluripotency and differentiation potential of stem cells. CST provides a comprehensive selection of antibodies to investigate epigenetic regulation and changes that impact phenotype and cell structure.

増殖因子

Growth factors direct stem cell development and differentiation towards distinct cell lineages. CST offers high-quality antibodies for the investigation and characterization of the cooperative actions of growth factors in differentiation and proliferation.

発生生物学

CST offers rigorously validated ELISA assay kits to measure the activity of signaling pathways involved in normal development and disease.

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