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線維症

線維症

線維症は臓器機能障害、疾病の罹患、死亡の原因となる、慢性炎症に対する病原性反応で、細胞外マトリクス (ECM) の過剰な沈着や組織の硬化などがみられます。感染症、自己免疫反応、毒素、放射線、機械的損傷などの様々な刺激が線維症を引き起こす原因となります。残念ながら、線維症の原因となるメカニズムは十分には理解されておらず、この疾患の効果的に治療するための大きな課題となっています。Cell Signaling Technology (CST) と当社エキスパートの研究者たちが、線維症の研究をサポートするために、高品質かつ検証済みの抗体や製品を提供するお手伝いをさせていただきます。

線維症におけるシグナル伝達経路に関する抗体

When developing therapeutics, it is important to understand the signaling pathways that contribute to the activation and maintenance of fibrotic cells such as myofibroblasts. CST offers a variety of validated antibodies to probe key fibrotic pathways to support your discovery research.

線維症における代謝に関する抗体

Metabolic changes are associated with fibrosis in a variety of organ types. Cell Signaling Technology (CST) offers a diverse selection of validated antibodies to advance the discovery and development of novel treatments targeting fibrotic metabolism.

線維症における免疫応答に関する抗体

Although the relationship between inflammation and fibrosis is deeply interconnected and has many overlapping mechanisms, the interplay between them is poorly understood. CST offers a wide variety of antibodies that can support your research into the immune-driven aspects of fibrosis pathogenesis.

細胞外マトリクスタンパク質に関する抗体

Extracellular matrix (ECM) is essential for normal tissue and cellular function and plays a role in differentiation, metabolism, proliferation, however, excessive accumulation can drive the progression of fibrosis. CST offers a diverse catalog of validated antibodies to better understand ECM proteins in support of your fibrosis research.

線維症における細胞死に関する抗体

There is increasing evidence that cell death can contribute to fibrosis at several stages - initiation, progression, and resolution of disease. CST provides validated antibodies to reliably measure cell death and the underlying mechanisms of fibrosis.

線維症におけるがんの微小環境に関する抗体

Fibrotic tissue in the tumor microenvironment (TME) supports cancer progression, survival, and metastasis. CST offers a diverse selection of antibodies to interrogate the architecture of the TME.

細胞骨格タンパク質に関する抗体

During fibrosis, activation of fibroblasts to become myofibroblasts is marked by changes in the cellular cytoskeleton. Activated fibroblasts are characterized by the expression of alpha smooth actin and the deposition of excessive collagens, fibronectin, and other components into the ECM. The validated and reliable antibodies offered by CST can be used to probe the proteins involved in the underlying changes of pro-fibrotic cells.

アッセイとキット

Assessing fibrotic activity by measuring collagen content and signaling molecules provides important information to advance the discovery of novel therapeutic targets. CST has reliable, time-saving assays to measure changes in protein expression and signaling to help advance fibrotic discovery research.

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