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タンパク質とパスウェイの略語

4EBP eIF4E binding protein
Abl Ableson leukemia oncogene cellular homolog
AC Adenylate cyclase (アデニル酸シクラーゼ)
ACTR Acetyltransferase, amplified in breast cancer-1
ADAP Adhesion and degranulation adaptor protein
Ag Antigen (抗原)
AIF Apoptosis-inducing factor
Akt AKT8 virus oncogene cellular homolog
AMPK AMP-activated protein kinase
ANT Adenine nucleotide translocation channel
AP1 Activator protein 1 (c-junとc-fos)
Apaf-1 Apoptotic protease activating factor 1
APC Adenomatous polyposis coli
APP β-Amyloid precursor protein (βアミロイド前駆体タンパク質)
APPs Acute phase proteins (急性期タンパク質)
AP Adapter protein with a PH and SH2 domain
ASIP Atypical PKC isotype-specific interacting protein
ASK Apoptosis signal-regulating kinase
ATF-2 Activating transcription factor 2
ATM Ataxia telangiectasia-mutated protein kinase
ATR ATM and Rad3-related protein kinase
BAFF B cell activating factor of TNF family/BLyS
Bam32 B cell adaptor molecule 32 kDa
BCAP B cell adaptor for PI3K
Bcl-10 B cell leukemia 10 protein
Bfl-1 Bcl-2-related protein A1
Bid A BH3 domain-only death agonist protein
Bimp1 B-lymphocyte-induced maturation protein 1
BLNK B cell linker protein
BLyS B lymphocyte stimulator/BAFF
BR3 BLyS receptor 3/BAFF-R
BRCA Breast cancer growth suppressor protein
Btk Bruton’s tyrosine kinase (ブルトン型チロシンキナーゼ)
β-TrCP β-transducin repeat-containing protein
C3G Guanine nucleotide-releasing factor 2 (GRF2)
CAD Caspase-activated deoxyribonuclease
Cam Calmodulin
CaMK Calcium/calmodulin-dependent kinase (カルシウム/カルモジュリン依存性キナーゼ)
cAMP Cyclic adenosine monophosphate (環状アデノシン一リン酸)
CAP c-Cbl-associated protein
Cas p130CAS, Crk-associated substrate
Caspase アスパラギン酸に特異的なシステインプロテアーゼ
Cav Caveolin
CBL Cellular homologue of Cas NS-1 oncogene
CBP CREB binding protein
cdc 細胞周期制御タンパク質
cdc2 Cyclin-dependent kinase 1 (CDK1)
cdc34 ユビキチン結合酵素 (E2)
cdc37 キナーゼに結合するシャペロン
cdc42 Rhoファミリーの低分子量Gタンパク質
CDK Cyclin-dependent kinase (サイクリン依存性キナーゼ)
Chk Checkpoint kinase
CHOP C/EBP homologous protein 10
c-IAP Cellular inhibitor of apoptosis protein
CIP CDK-interacting protein
CIS Cytokine inducible SH2-containing protein
CK Casein kinase (カゼインキナーゼ)
c-Myb Avian myeloblastosis virus oncogene cellular homolog
c-Myc Avian myelocytomatosis virus oncogene cellular homolog
Cot Cancer osaka thyroid、セリン/スレオニンキナーゼの一種
cPLA2 Cytoplasmic phospholipase A2
CREB cAMP response element-binding protein
CRK CT10 sarcoma oncogene cellular homolog
CTMP Carboxyl-terminal modulator protein
DAG Diacylglycerol (ジアシルグリセロール)
DAPK Death-associated protein kinase
Daxx Fas death domain-associated protein
Diablo Direct IAP binding protein with low pI
DNA-PK DNA-activated protein kinase
DP1 DRTF1-polypeptide-1、 転写因子の一種
DPC4 Deleted in pancreatic cancer locus 4 (Smad4としても知られる)
DR Death receptor (細胞死受容体)
Dsh Dishevelled
dsRNA Double-stranded RNA (二本鎖RNA)
E2F Transcription factor family including E2F- and DP-like subunits
eEF Eukaryotic elongation factor
Egr-1 Early growth response protein 1
EHD1 EH domain-containing 1
eIF Eukaryotic initiation factor
Elk Ets-like transcription factor
ENaC Epithelial sodium channel
Endo G Endonuclease G
eNOS Endothelial nitric oxide synthase
EPAC Exchange protein activated by cAMP
ER Estrogen receptor (エストロゲン受容体) または Endoplasmic reticulum (小胞体)
Erk Extracellular signal-regulated kinase
Ets E26-AMV virus oncogene cellular homolog、転写因子の一種
FADD Fas-associated protein with death domain
FAK Focal adhesion kinase
Fas TNF superfamily receptor 6
FcgRII IgG Fc receptor II
FKHR Forkhead in rhabdomyosarcoma
FLIP FLICE (Caspase-8) inhibitory protein
FRAP FKBP12-rapamycin-associated protein
FRS FGF receptor substrate
Fyn A Src family tyrosine-protein kinase
Gab1 GRB2-associated binder-1
GADD Growth arrest and DNA damage protein
GAP GTPase activating proteins (GTPase活性化タンパク質)
GAS IFN-γ-activated sequences
Gas2 Growth arrest-specific gene 2
GBP GSK-3 binding protein
GCK Germinal center kinase
GCN General control of amino acid biosynthesis protein
GEF Guanine nucleotide exchange factor (グアニンヌクレオチド交換因子)
GF-Rs Growth factor receptors
GLUT4 Glucose transporter type 4
GPCR G-protein coupled receptor (Gタンパク質共役型受容体)
GRB Growth factor receptor-bound protein
GRIP Glucocorticoid receptor interacting protein
GRK G-protein coupled receptor kinase
GSK Glycogen synthase kinase
HDAC Histone deacetylase
HIPK Homeodomain-interacting protein kinase
HMG High mobility group
HPK Hematopoietic progenitor kinase
HRI Hemin-regulated inhibitor
Hrk/DP5 Harakiri protein、 アポトーシス促進因子
HSF1 Heat-shock factor 1
HSP Heat shock protein (熱ショックタンパク質)
HtrA2 High temperature requirement serine protease A2
IAP Inhibitor of apoptosis
ICAD Inhibitor of caspase-activated deoxyribonuclease
IκB Inhibitor of NF-κB
IKK IκB kinase
ILK Integrin-linked kinase
INK4 Inhibitor of CDK4
iNOS Nitric oxide synthase, inducible
IP3 Inositol trisphosphate (イノシトール三リン酸)
IRAK Interleukin 1 receptor-associated kinase 1
IRS Insulin receptor substrate
ISRE Interferon-stimulated response element
ITAM immunoreceptor tyrosine-base activation motifs
Jak Janus-family tyrosine kinase
JIP JNK-interacting protein
JNK Jun N-terminal kinase
KSR Kinase suppressor of Ras
LAB Linker for activation of B cells
LAT Linker for activation of T cells
LC8 Dynein light chain, cytoplasmic
LCK Lymphocyte-specific protein-tyrosine kinase
LRP LDL-receptor-related protein
LT Lymphotoxin
LTβR Lymphotoxin-β receptor
Lyn A src family tyrosine-protein kinase
M3/6 二重特異性ホスファターゼ
MAGUKs Membrane-associated guanylate kinase homologs
MALT Mucosa-associated lymphoma translocation protein
MAPK Mitogen-activated protein kinase
MAPKAP MAP kinase activated protein kinase
Mcl-1 Myeloid cell leukemia 1
MDM2 Murine double minute 2
MEF2 Myocyte enhancer factor 2
MEK MAPK/Erk kinase
MEKK MAPK/Erk kinase kinase
MHC Major histocompatibility complex (主要組織適合遺伝子複合体)
mIg Membrane immunoglobulin
MKP MAP kinase phosphatase
MLCK Myosin light chain kinase
MLK Mixed lineage kinase
MNK MAP kinase interacting kinase
MP-1 MEK partner 1
Mre11 Meiotic recombination 11
MSK Mitogen and stress activated kinase
mTOR Mammalian target of rapamycin
Myc Myelocytomatosis oncogene cellular homolog
MyD88 Myeloid differentiation factor 88
MyoD Myogenic determination factor
Myt1 二重特異性キナーゼの一種
NAK NF-κB-activating kinase
NAP1 Nck-associated protein 1
NBS1 Nijmegen breakage syndrome 1
Nck Nck adaptor protein
NcoR Nuclear receptor corepressor
Nemo IKKγ、IKK調節サブユニットの一つ
NFAT Nuclear factor of activated T cells
NF-kB Nuclear factor κ B
NIK NF-κB-inducing kinase
NLK Nemo-like kinase
NO Nitric oxide (一酸化窒素)
Noxa Damage protein、BH3を含むアポトーシス促進因子
NRG Neuregulin
Oct Octamer-binding transcription factor 2
p19Arf p19 alternative reading frame protein
p300 A histone acetyltransferase
p53 Tumor suppressor protein that protects from DNA damage
p90RSK 90 kDa ribosomal S6 kinase
PABP Poly (A) tail-binding protein
PAIP Polyadenylate binding protein-interacting proteins
PAK p21-activated kinase
PAR-1 Partitioning protein 1
PARP Poly (ADP-ribose) polymerase
Pax Paxillin
PCAF p300/CBP-associated factor
pCIP p300/CBP-interacting protein
PDE3B cGMP-inhibited 3’,5’-cyclic phosphodiesterase B
PDK 3-phosphoinositide-dependent protein kinase
PEK Pancreatic eukaryotic initiation factor 2a-subunit kinase
PERK Type I transmembrane ER-resident protein kinase
PI3K Phosphoinositide 3 kinase
PIAS Protein inhibitors of activated Stats
PIP2 Phosphatidylinositol 3,4-bisphosphate
PIP3 Phosphatidylinositol 3,4,5-trisphosphate
PKA Protein kinase A
PKC Protein kinase C
PKR Protein kinase R、二本鎖RNA依存性セリン/スレオニンキナーゼ
PLA Phospholipase A
PLC Phospholipase C
Plk Polo-like kinase
PLP2A Phospholipase A2
POSH Plenty Of SH3s
PP1 Phospho-protein phosphatase 1
PP2A Phospho-protein phosphatase 2A
PPAR Peroxisome proliferator-activated receptor
PR Progesterone receptor
PRAK p38 regulated activated kinase
PRK2 Protein kinase C-related kinase 2
PTEN Phosphatase and tensin homologue deleted on chromosome 10
PTP1B Protein phosphotyrosylphosphatase 1B
PUMA p53 upregulated modulator of apoptosis
Pygo Pygopus
PYK Proline-rich tyrosine kinase
RAIDD RIP-associated ICH/CED-3-homologous protein with a death domain
Rap1 Ras-related protein RAP-1A
RAR Retinoic acid receptor
RasGRP Ras guanyl nucleotide-releasing protein
Rb Retinoblastoma protein
Rel Reticuloendotheliosis oncogene cellular homolog
RGS Regulator of G-protein signaling
Rheb Ras homolog enriched in brain
RIP Receptor-interacting protein
ROCK Rho-associated, coiled-coil-containing protein kinase
ROIs Reactive oxygen intermediates
RSK Ribosomal protein S6 kinase
RTK Receptor tyrosine kinase
RXR Retinoid X receptor
S6 Small subunit ribosomal protein S6
SAPK Stress-activated protein kinase
SARA Smad Anchor for Receptor Activation
SCF Skp-cdc53-F-box ubiquitin ligase complex
SGK Serum/glucocorticoid-regulated kinase
Shc SH2-containing collagen-related proteins
SHIP SH2-containing inositol phosphatase
SHP1 SH2-containing phosphatase 1
SHP2 SH2-containing phosphatase 2
Sin3 A transcriptional corepressor
SIRT2 Silent information regulator 2
SKP2 S-phase kinase-associated protein 2
SLP76 SH2 domain-containing leukocyte protein, 76-kd
Smac Second mitochondria-derived activator of caspase
Smad Contraction of Sma and Mad (Mothers against decapentaplegic)
SMRT Silencing mediator of retinoic acid and thyroid hormone receptor
Smurf Smad ubiquitination regulatory factor
SNARE Soluble N-ethylmaleimide attachment protein receptors
SOCS Suppressor of cytokine signaling
SOS Son of sevenless guanine nucleotide exchange factor
SOX Sry-box transcription factors
Src Rous sarcoma oncogene cellular homolog
SRC1 Steroid receptor coactivator 1
SRF Serum response factor
Stat Signal transducer and activator of transcription
SUMO Small ubiquitin-like modifier
Suv39h1 Position-effect-variegation protein Su(var)3-9
Syk Spleen tyrosine kinase
Synip Syntaxin 4-interacting protein
TAB TAK binding protein
TAFs TBP-associated factors
TAK TGF β-activated kinase
Tal Talin
Tax Transactivator protein of HTLV-1
tBid Truncated Bid
TBP TATA-binding protein (TATA結合タンパク質)
TC10 GTP-binding protein TC10
TCF T cell factor
TCR T cell receptor
TF Transcription factor (転写因子)
TGF Transforming growth factor
TGIF TG-interacting factor
TH Tyrosine hydroxylase
Tip60 HIV1 Tat interacting protein
TIRAP TIR domain-containing adaptor protein
TNF Tumor necrosis factor (腫瘍壊死因子)
Topo II DNA topoisomerase II
Tpl2 Tumor progression locus2 (Cot1、MAP3K8)
TR Thyroid hormone receptor
TRADD TNF receptor-1-associated death domain protein
TRAF TNF receptor-associated factor
TRAIL TNF-related apoptosis-inducing ligand
TRAM Trif-related adaptor molecule
TRIF Tir domain-containing adaptor inducing interferon-beta
TSC Tuberous sclerosis complex (結節性硬化症)
TWEAK TNF-related weak inducer of apoptosis
ub Ubiquitin (ユビキチン)
UV Ultraviolet radiation
VASP Vasodilator-stimulated phosphoprotein
Vav The ‘onc F’ proto-oncogene
Wee1 Small cell protein, a mitotic inhibitor kinase
XIAP Inhibitor of apoptosis, x-linked
YAP Yes-Associated Protein 1
Zap-70 z-chain-associated protein kinase
改訂日:2007年5月
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