|Molecular Weight||500.6 g/mol|
|Solubility||Soluble in DMSO at 70 mg/mL.|
Adavosertib (MK-1775) is a potent, selective Wee1 kinase inhibitor with an IC50 value of 5.2 nM. Adavosertib inhibits phosphorylation of the Wee1 substrate Cdc2 at Tyr15, thereby abrogating the G2 DNA damage checkpoint (1). Wee1 inhibition in p53-deficient tumors by Adavosertib has been shown to inhibit and regress tumor growth (2).
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