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31403
Ascomycin (FK520)
活性化剤 & 阻害剤
化学調節物質

Ascomycin (FK520) #31403

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Chemical structure of Ascomycin (FK520).

製品概要

Ascomycin (FK520) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

保存

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 792.0 g/mol

Purity: >99%

Molecular Formula: C43H69NO12

CAS: 104987-12-4

Solubility: Soluble in DMSO at 50 mg/ml or ethanol at 50 mg/ml with slight warming.

バックグラウンド

Ascomycin (FK520) is a 23-membered macrolide lactone produced from the fermentation of Streptomyces hygroscopicus (1). A natural analogue of FK506, Ascomycin (FK520) has the ability to bind to FK506-binding protein 12 (FKBP12), inhibiting calcineurin phosphatase activity, and disrupting the activation of nuclear factor of activated T cells (NFAT) and other various substrates (2). Primarily described as an antifungal antibiotic, Ascomycin (FK520) has shown to be a potent immunosuppressant (IC50 = 0.55 nM) used to prevent the rejection of organ transplants and skin allografts (1,3). Ascomycin (FK520) displays powerful antimalarial properties independent of its immunosuppressive mechanisms of action (2).

  1. Hatanaka, H. et al. (1988) J Antibiot (Tokyo) 41, 1592-601.
  2. Monaghan, P. et al. (2005) J Infect Dis 191, 1342-9.
  3. Arndt, C. et al. (1999) Microbiology 145 (Pt 8), 1989-2000.
研究用のみ。診断手順では使用しません。

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 31403S
製品番号 サイズ 価格 在庫
31403S
5 mg

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