Captopril is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.15 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
|Molecular Weight||217.3 g/mol|
|Solubility||Soluble in DMSO at 20 mg/ml or water at 20 mg/ml.|
Captopril is a selective and reversible angiotensin-converting enzyme (ACE) inhibitor with an IC50 value of 0.022 μM (1). This small molecule selectively lowers angiotensin II, a hormone that when upregulated has been linked to increased hypertension, atherosclerosis, myocardial hypertrophy, and obesity (2-5). Captopril has also been shown to regulate inflammatory pathways as a reversible inhibitor of leukotriene A4 (LTA4) hydrolase, reducing leukotriene B4 synthesis (6).
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