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72997
Ivermectin
Activators & Inhibitors
Chemical Modulators

Ivermectin #72997

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other Image 1 - Ivermectin

Chemical structure of Ivermectin.

Product Usage Information

Ivermectin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 mg of powder in 1.14 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 875.1 g/mol

Purity: >98%, contains up to 10% B1b form.

Molecular Formula: C48H74O14 (B1a form)

CAS: 70288-86-7

Solubility: Soluble in DMSO at 70 mg/ml or ethanol at 25 mg/ml.

Background

Ivermectin is a positive allosteric modulator of the ATP-activated ion channel, P2X purinoceptor 4 (P2X4), as well as the α7 neuronal nicotinic acetylcholine receptor (α7-nAChR) (1,2). The α7-nAChR is required for the cytokine suppressing mechanism of the inflammatory reflex and it stimulates activation of calcium ion transport. Impairment of the α7-nAChR can lead to overproduction of cytokines and a heightened inflammatory response (3). Ivermectin is a known anthelmintic agent, activating the glutamate-gated chloride channels in the nerves and muscles of parasites. The disruption of the parasite’s ingestive activity eventually leads to starvation (4). Ivermectin has been shown to inhibit SARS-CoV-2 replication in vitro with an IC50 value of ~2 μM (5).

  1. Krause, R.M. et al. (1998) Mol Pharmacol 53, 283-94.
  2. Khakh, B.S. et al. (1999) J Neurosci 19, 7289-99.
  3. Zdanowski, R. et al. (2015) Cent Eur J Immunol 40, 373-9.
  4. Priel, A. and Silberberg, S.D. (2004) J Gen Physiol 123, 281-93.
  5. Caly, L. et al. (2020) Antiviral Res 178, 104787.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 72997S
製品番号 サイズ 価格 在庫
72997S
100 mg

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