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24718
Mycophenolic Acid
Activators & Inhibitors
Chemical Modulators

Mycophenolic Acid #24718

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Chemical structure of Mycophenolic Acid.

Product Usage Information

Mycophenolic Acid is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.04 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 320.3 g/mol

Purity: >98%

Molecular Formula: C17H20O6

CAS: 24280-93-1

Solubility: Soluble in DMSO at 30 mg/ml or ethanol at 30 mg/ml.

Background

Mycophenolic Acid, also referred to as MPA, is a potent inhibitor of the enzyme inosine 5’-monophosphate dehydrogenase (IMPDH), a key molecule in the biosynthesis of guanine nucleotides. This inhibition leads to suppression of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages (1). Mycophenolic Acid has been shown to inhibit the reproduction of the Middle East respiratory syndrome coronavirus (MERS-CoV) with an IC50 of 2.87 µM (2). Clinically, Mycophenolic Acid has been used as an anti-rejection immunosuppressant medication for kidney and liver transplant patients (3,4).

  1. Jonsson, C.A. and Carlsten, H. Cell Immunol 216, 93-101.
  2. Hart, B.J. et al. (2014) J Gen Virol 95, 571-7.
  3. Chen, H. and Chen, B. (2014) World J Gastroenterol 20, 10715-28.
  4. Zwart, T.C. et al. (2018) Br J Clin Pharmacol 84, 2889-902.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 24718S
Product # Size Price Inventory
24718S
50 mg

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