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27793
Nelfinavir Mesylate
Activators & Inhibitors
Chemical Modulators

Nelfinavir Mesylate #27793

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other Image 1 - Nelfinavir Mesylate

Chemical structure of Nelfinavir Mesylate.

Product Usage Information

Nelfinavir Mesylate is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 753 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 663.9 g/mol

Purity: >98%

Molecular Formula: C32H45N3O4S • CH3SO3H

CAS: 159989-65-8

Solubility: Soluble in DMSO at 70 mg/ml.

Background

Nelfinavir Mesylate, also known as AG-1343, is a potent antiviral inhibitor of HIV-1 protease with a Ki value of 2 nM, in vitro (1). This small molecule is an effective antitumor agent, known to induce endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo (2). Nelfinavir Mesylate has anti-microbial effects on malaria, tuberculosis, and SARS (3). It has also been used in therapies as an antifibrotic agent against pulmonary fibrosis in patients with systemic sclerosis (4). Nelfinavir Mesylate is known to reduce inflammation by activating protein phosphatase 2 (PP2) and blocking MAPK signaling in macrophages (5). Through a novel mechanism of heat shock protein 90 (HSP90) inhibition, Nelfinavir Mesylate selectively inhibits the growth of HER2-positive breast cancer cells in vitro (6).

  1. Patick, A.K. et al. (1996) Antimicrob Agents Chemother 40, 292-7.
  2. Gills, J.J. et al. (2007) Clin Cancer Res 13, 5183-94.
  3. Brüning, A. et al. (2010) Curr Mol Pharmacol 3, 91-7.
  4. Sanchez, C.G. et al. (2018) Arthritis Rheumatol 70, 115-26.
  5. Wallet, M.A. et al. (2012) J Leukoc Biol 92, 795-805.
  6. Shim, J.S. et al. (2012) J Natl Cancer Inst 104, 1576-90.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 27793S
製品番号 サイズ 価格 在庫
27793S
25 mg

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