Chemical structure of T-705 (Favipiravir).
T-705 (Favipiravir) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 2 mg of powder in 1.27 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Molecular Weight: 157.1 g/mol
Molecular Formula: C5H4FN3O2
Solubility: Soluble in DMSO at 30 mg/ml or water at 12 mg/ml with slight warming.
T-705 (Favipiravir) is a potent antiviral agent that has shown effectiveness against influenzas A, B, and C with IC50 values as follows: A (H1N1) = 0.03-0.20 µg/ml, A (H2N2) = 0.01-0.30 µg/ml, A (H3N2) = 0.08-0.48 µg/ml, A (H4N2) = 0.14-0.15 µg/ml, A (H7N2) = 0.24-1.60 µg/ml, B = 0.04-0.09 µg/ml, and C = 0.03-0.06 µg/ml (1,2). T-705 (Favipiravir) becomes activated by phosphoribosylation to form T-705 (Favipiravir)-RTP that is recognized by RNA polymerase, inhibiting RNA-dependent RNA polymerase (RdRP). This activity makes T-705 (Favipiravir) an effective inhibitor of other RNA viruses, such as arena-, phlebo-, hanta-, flavi-, entero-, and alphavirus. The antiviral capability of T-705 (Favipiravir) makes it a compound of interest when studying SARS-CoV-2 infection (3).
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