GBA Antibodies

Target Information

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol. Belongs to the glycosyl hydrolase 30 family. 5 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

acid beta glucosidase; Acid beta-glucosidase; Alglucerase; Beta-GC; Beta-glucocerebrosidase; betaG; betaGC; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; GBA; Gba; GBA1; GC; GCa; GCase; GCB; GLCM; GLUC; glucocerebrosidase; glucosidase, beta, acid; Glucosylceramidase; glucosylceramidase beta; glucosylceramidase-like protein; Imiglucerase; Lysosomal acid GCase; Lysosomal acid glucosylceramidase; lysosomal glucocerebrosidase; SGTase