TEAD3 Antibodies

Target Information

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Preferentially expressed in the placenta. Note: This description may include information from UniProtKB.

Alternate Names

DTEF-1; ETFR-1; TEA domain family member 3; TEA domain family member 5; TEA domain transcription factor 3; TEAD-3; TEAD3; TEAD5; TEF-5; TEF5; transcriptional enhancer factor 5; Transcriptional enhancer factor TEF-5; Transcriptional enhancer factor TEF-5 (DTEF-1)