Render Target: STATIC
Render Timestamp:
6/4/2026, 8:14:17 PM EDT
6/5/2026, 12:14:17 AM UTC
Commit: 33ae406c5df2bbc7a7d3c17605228fbeff8ea416
XML generation date: 2025-11-13 17:58:07.355
Product last modified at: 2026-03-20T08:07:04.933Z
Cell Signaling Technologyロゴ - Extra Large
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

GP130 Antibody #3732

Filter:
  • WB

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 130
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    プロトコール

    Specificity / Sensitivity

    GP130 Antibody detects endogenous levels of total GP130 protein independent of phosphorylation.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human GP130. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    GP130 is a signal-transducing subunit shared by the receptors for the interleukin-6 (IL-6) family of cytokines (1-3). The binding of a ligand to its receptor induces GP130 dimerization, leading to Jak tyrosine kinase activation and GP130 tyrosine phosphorylation. These events lead to the activation of multiple signal-transduction pathways, such as the Stat, Ras-MAPK, and PI3 kinase pathways, whose activation is controlled by distinct regions of GP130 (4-7).

    Alternate Names

    CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; GP130-RAPS; gp130, oncostatin M receptor; HIES4; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6RB; IL6ST; IL6ST nirs variant 3; interleukin 6 signal transducer; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; Oncostatin-M receptor subunit alpha; sGP130

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.