Render Target: STATIC
Render Timestamp:
6/4/2026, 7:31:11 PM EDT
6/4/2026, 11:31:11 PM UTC
Commit: 33ae406c5df2bbc7a7d3c17605228fbeff8ea416
XML generation date: 2025-11-12 16:09:32.603
Product last modified at: 2026-03-20T08:10:57.119Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
Trial Size Available Flag

MSH2 (3A2) Mouse Monoclonal Antibody #2850

Filter:
  • WB
  • IP
  • IF

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Mouse IgG1
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunofluorescence (Immunocytochemistry) 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    プロトコール

    Specificity / Sensitivity

    MSH2 (3A2) Mouse Monoclonal Antibody detects endogenous levels of total MSH2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant human MSH2.

    Background

    The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).
    Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.

    Alternate Names

    COCA1; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2 transcript; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MSH2; mutS homolog 2; mutS homolog 2, colon cancer, nonpolyposis type 1; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); MutS protein homolog 2

    For Research Use Only. Not for Use in Diagnostic Procedures.
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