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PTMScan® Direct PI3K/Aktサービスでは、創薬、バイオマーカーの探索、診断法の開発に重要なタンパク質の修飾部位やシグナルの分岐点を、PI3K/Akt経路およびその関連タンパク質に標的を絞ってスクリーニング、定量を行います。下の表は、PTMScan® Direct PI3K/Aktサービスで検出可能なタンパク質修飾部位の一覧です。
PTMScan® Direct PI3K/Aktサービスは、105種のタンパク質の固有のリン酸化部位296サイトを同定し、定量的にプロファイリングする安定した方法です。
| PI3K/Akt pathwayでモニター可能なタンパク質修飾部位 | |||
|---|---|---|---|
| PI3K/Akt pathwayでモニター可能なタンパク質修飾部位 | |||
| 4E-BP1 (Ser35) | 4E-BP1 (Ser44) | 4E-BP1 (Thr36) | 4E-BP1 (Thr37) |
| 4E-BP1 (Thr41) | 4E-BP1 (Thr45) | 4E-BP1 (Thr46) | 4E-BP1 (Thr50) |
| 4E-BP1 (Tyr34) | 4E-BP1 (Tyr54) | 4E-BP2 (Ser44) | 4E-BP2 (Thr36) |
| 4E-BP2 (Thr37) | 4E-BP2 (Thr41) | 4E-BP2 (Thr45) | 4E-BP2 (Thr46) |
| 4E-BP2 (Thr50) | 4E-BP2 (Tyr34) | 4E-BP2 (Tyr54) | 4E-BP3 (Thr23) |
| 4E-BP3 (Thr27) | 4E-BP3 (Thr31) | 4E-BP3 (Thr32) | ACTB (Thr201) |
| ACTG1 (Thr201) | Akt1 (Ser473) | Akt1 (Thr305) | Akt1 (Thr308) |
| Akt1 (Thr312) | Akt1 (Tyr315) | Akt2 (Ser474) | Akt2 (Ser476) |
| Akt2 (Ser478) | Akt2 (Thr309) | Akt2 (Thr313) | Akt2 (Tyr316) |
| Akt2 (Tyr475) | Akt3 (Ser472) | Akt3 (Ser474) | Akt3 (Ser476) |
| Akt3 (Thr298) | Akt3 (Thr305) | Akt3 (Tyr473) | ATR (Ser435) |
| ATR (Ser436) | BAD (Ser71) | BAD (Ser74) | BAD (Ser75) |
| BAD (Ser91) | BAD (Ser97) | BAD (Ser99) | BAD (Thr80) |
| BAD (Tyr76) | CTNND1 iso3 (Ser168) | CTNND1 iso3 (Thr147) | CTNND1 iso3 (Thr149) |
| CTNND1 iso3 (Thr152) | CTNND1 iso4 (Ser168) | CTNND1 iso4 (Thr147) | CTNND1 iso4 (Thr149) |
| CTNND1 iso4 (Thr152) | CTNND1 (Ser168) | CTNND1 (Thr147) | CTNND1 (Thr149) |
| CTNND1 (Thr152) | DNMT1 iso2 (Ser748) | DNMT1 (Ser732) | Dok1 (Tyr341) |
| Dok2 (Tyr299) | eIF4H (Ser230) | eIF4H (Thr217) | eIF4H (Thr220) |
| EphA2 (Thr593) | EphA2 (Thr771) | EphA2 (Thr773) | EphA2 (Thr774) |
| EphA2 (Tyr588) | EphA2 (Tyr772) | FAK iso2 (Ser211) | FAK iso2 (Ser422) |
| FAK iso2 (Thr227) | FAK iso2 (Tyr216) | FAK iso2 (Tyr424) | FAK iso2 (Tyr425) |
| FAK (Ser392) | FAK (Ser574) | FAK (Thr408) | FAK (Tyr397) |
| FAK (Tyr576) | FAK (Tyr577) | FOXK1 (Thr273) | FOXO1A (Ser256) |
| FOXO3A (Ser43) | FOXO3A (Ser48) | FOXO3A (Ser55) | FOXO3A (Thr51) |
| Fyn iso2 (Tyr417) | Fyn (Tyr420) | GAPDH (Thr153) | GOLGA3 (Ser1430) |
| GOLGA3 (Ser983) | GOLGA4 (Ser40) | GOLGA4 (Ser41) | GOLGA4 (Thr39) |
| GOLGA4 (Thr43) | GSK3A (Ser20) | GSK3A (Ser21) | GSK3A (Ser39) |
| GSK3A (Ser41) | GSK3A (Thr19) | GSK3A (Thr46) | HGK iso5 (Ser908) |
| HGK iso5 (Thr187) | HGK iso5 (Thr910) | HGK iso7 (Ser463) | HGK iso7 (Ser934) |
| HGK iso7 (Thr127) | HGK iso7 (Thr936) | HGK (Ser523) | HGK (Ser913) |
| HGK (Thr187) | HGK (Thr915) | HRas (Tyr32) | HRas (Tyr64) |
| IRS1 (Ser303) | IRS1 (Ser307) | IRS1 (Ser312) | IRS1 (Ser315) |
| IRS1 (Ser323) | IRS1 (Ser603) | IRS1 (Ser604) | IRS1 (Ser616) |
| IRS1 (Thr305) | IRS1 (Thr309) | IRS1 (Thr311) | IRS1 (Thr608) |
| IRS1 (Tyr1179) | IRS1 (Tyr612) | IRS2 (Ser594) | IRS2 (Tyr598) |
| KHSRP (Ser132) | KRas iso2 (Tyr32) | KRas iso2 (Tyr64) | KRas (Tyr32) |
| KRas (Tyr64) | lamin A/C iso2 (Ser404) | lamin A/C iso2 (Ser406) | lamin A/C (Ser404) |
| lamin A/C (Ser406) | Lck (Tyr394) | LOC647000 (Ser41) | MEK1 (Ser218) |
| MEK1 (Ser222) | MEK1 (Thr226) | MEK2 (Ser222) | MEK2 (Ser226) |
| MEK2 (Thr230) | MINK iso4 (Thr187) | MINK (Thr187) | MST3 iso2 (Thr170) |
| MST3 iso2 (Thr172) | MST3 iso2 (Thr178) | MST3 iso2 (Thr182) | MST3 (Thr182) |
| MST3 (Thr184) | MST3 (Thr190) | MST3 (Thr194) | MST4 (Thr320) |
| MST4 (Thr327) | mTOR (Ser2442) | mTOR (Ser2448) | mTOR (Ser2450) |
| mTOR (Ser2454) | mTOR (Ser2478) | mTOR (Ser2481) | mTOR (Thr2444) |
| mTOR (Thr2446) | mTOR (Thr2471) | mTOR (Thr2473) | mTOR (Thr2474) |
| mTOR (Tyr2449) | MYPT1 (Ser802) | MYPT1 (Ser910) | MYPT1 (Thr453) |
| MYPT1 (Tyr446) | MYPT1 (Tyr766) | MYPT1 (Tyr901) | MYPT1 (Tyr911) |
| NDRG1 (Ser344) | NDRG1 (Ser352) | NDRG1 (Ser354) | NDRG1 (Ser357) |
| NDRG1 (Ser362) | NDRG1 (Ser364) | NDRG1 (Ser367) | NDRG1 (Ser378) |
| NDRG1 (Ser384) | NDRG1 (Ser389) | NDRG1 (Ser393) | NDRG1 (Thr346) |
| NDRG1 (Thr356) | NDRG1 (Thr360) | NDRG1 (Thr366) | NDRG1 (Thr375) |
| NF-GMB iso2 (Ser134) | NF-GMB iso2 (Tyr131) | NF-GMB (Ser134) | NF-GMB (Tyr131) |
| NF-κB p105 (Ser907) | NRas (Tyr32) | NRas (Tyr64) | Nur77 (Ser351) |
| Nur77 (Ser360) | PAK2 (Ser19) | PAK2 (Ser20) | PAK2 (Ser32) |
| PAK2 (Ser36) | PAK2 (Ser42) | PAK2 (Thr21) | PAK2 (Thr25) |
| PAR-4 (Ser231) | PAR-4 (Ser233) | PAR-4 (Thr229) | PAR-4 (Tyr177) |
| PDK1 iso2 (Ser114) | PDK1 (Ser241) | PDPK2 (Ser214) | PIK3CA (Ser507) |
| PIK3CA (Ser509) | PIK3R1 (Tyr467) | PIK3R2 (Tyr464) | PIK3R3 (Tyr199) |
| PIK3R5 (Ser507) | PIK4CB iso2 (Ser256) | PIK4CB (Ser256) | PKA RI-α (Ser375) |
| PKCα (Thr494) | PKCα (Thr497) | PKCα (Tyr504) | PKCβ iso2 (Thr498) |
| PKCβ iso2 (Thr500) | PKCβ (Thr498) | PKCβ (Thr500) | PKCI (Thr412) |
| PKD2 (Ser375) | PRAS40 (Ser203) | PRAS40 (Thr266) | PTEN (Ser385) |
| RANBP3 iso3 (Ser57) | RANBP3 iso3 (Ser58) | RANBP3 iso3 (Thr56) | RANBP3 iso3 (Thr60) |
| RANBP3 (Ser125) | RANBP3 (Ser126) | RANBP3 (Thr124) | RANBP3 (Thr128) |
| Raptor (Ser719) | Raptor (Ser722) | Rictor (Ser1320) | RSK2 (Ser386) |
| S6 (Ser235) | S6 (Ser236) | S6 (Ser240) | S6 (Ser242) |
| S6 (Ser244) | S6 (Ser246) | S6 (Ser247) | S6 (Thr241) |
| SGK3 (Ser315) | SGK3 (Thr318) | Shb (Ser323) | Shb (Tyr336) |
| SHIP-2 (Tyr886) | Src (Tyr419) | TUBA1A (Ser287) | TUBA1B (Ser287) |
| TUBA3C (Ser287) | TUBA3D (Ser287) | TUBA3E (Ser287) | TUBA4A (Ser287) |
| TUBB2A (Ser339) | TUBB2B (Ser339) | TUBB2C (Ser339) | TUBB3 (Ser339) |
| TUBB4 (Ser339) | TUBB6 (Ser339) | TUBB (Ser339) | XIAP (Ser123) |
| YB-1 (Ser102) | YB-1 (Thr108) | YB-1 (Tyr99) | Yes (Tyr426) |
| YSK1 (Thr166) | YSK1 (Thr168) | YSK1 (Thr174) | YSK1 (Thr178) |
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