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PTMScan® Direct Tyrosine Kinaseサービスは、創薬、バイオマーカーの探索、診断法の開発において重要なタンパク質修飾部位を、チロシンキナーゼカイノームに含まれるタンパク質に標的を絞ってスクリーニングし定量します。下の表は、PTMScan® Direct Tyrosine Kinaseサービスで検出可能なタンパク質修飾部位の一覧です。
PTMScan® Direct Tyrosine Kinaseサービスは、120種のタンパク質の固有のリン酸化部位671部位を同定し、定量的にプロファイリングする確実な方法です。
| チロシンタンパク質と修飾部位 | |||
|---|---|---|---|
| チロシンタンパク質と修飾部位 | |||
| A6 iso2 (Tyr343) | A6 (Tyr309) | Abl iso2 (Tyr112) | Abl iso2 (Tyr134) |
| Abl iso2 (Tyr147) | Abl iso2 (Tyr158) | Abl iso2 (Tyr191) | Abl iso2 (Tyr204) |
| Abl iso2 (Tyr245) | Abl iso2 (Tyr251) | Abl iso2 (Tyr272) | Abl iso2 (Tyr276) |
| Abl iso2 (Tyr283) | Abl iso2 (Tyr412) | Abl iso2 (Tyr432) | Abl iso2 (Tyr488) |
| Abl (Tyr115) | Abl (Tyr128) | Abl (Tyr139) | Abl (Tyr172) |
| Abl (Tyr185) | Abl (Tyr215) | Abl (Tyr226) | Abl (Tyr232) |
| Abl (Tyr253) | Abl (Tyr257) | Abl (Tyr264) | Abl (Tyr393) |
| Abl (Tyr413) | Abl (Tyr469) | Abl (Tyr93) | Ack iso3 (Tyr596) |
| Ack iso3 (Tyr937) | Ack iso3 (Tyr938) | Ack iso3 (Tyr946) | Ack (Tyr284) |
| Ack (Tyr518) | Ack (Tyr859) | Ack (Tyr860) | Ack (Tyr868) |
| Ack (Tyr872) | Ack (Tyr874) | ALK (Tyr1078) | ALK (Tyr1092) |
| ALK (Tyr1096) | ALK (Tyr1131) | ALK (Tyr1278) | ALK (Tyr1282) |
| ALK (Tyr1283) | ALK (Tyr1359) | ALK (Tyr1507) | ALK (Tyr1584) |
| ALK (Tyr1586) | ALK (Tyr1604) | Arg iso4 (Tyr125) | Arg iso4 (Tyr403) |
| Arg (Tyr161) | Arg (Tyr174) | Arg (Tyr310) | Arg (Tyr439) |
| Arg (Tyr683) | Arg (Tyr718) | Arg (Tyr719) | Axl (Tyr696) |
| Axl (Tyr697) | Axl (Tyr698) | Axl (Tyr702) | Axl (Tyr703) |
| Axl (Tyr726) | Axl (Tyr755) | Axl (Tyr759) | Axl (Tyr866) |
| Blk (Tyr181) | Blk (Tyr182) | Blk (Tyr187) | Blk (Tyr188) |
| Blk (Tyr389) | Blk (Tyr494) | Blk (Tyr501) | Brk (Tyr114) |
| Brk (Tyr447) | Btk (Tyr223) | Btk (Tyr225) | Btk (Tyr334) |
| Btk (Tyr344) | Btk (Tyr361) | Btk (Tyr375) | Btk (Tyr511) |
| Btk (Tyr551) | CCK4 (Tyr872) | CLK3 (Tyr163) | CSFR (Tyr556) |
| CSFR (Tyr699) | CSFR (Tyr809) | CSK (Tyr263) | DDR1 (Tyr484) |
| DDR1 (Tyr513) | DDR1 (Tyr520) | DDR1 (Tyr790) | DDR1 (Tyr792) |
| DDR1 (Tyr794) | DDR1 (Tyr796) | DDR1 (Tyr797) | DDR1 (Tyr869) |
| DDR1 (Tyr881) | DDR2 (Tyr471) | DDR2 (Tyr481) | DDR2 (Tyr521) |
| DDR2 (Tyr735) | DDR2 (Tyr736) | DDR2 (Tyr739) | DDR2 (Tyr740) |
| DDR2 (Tyr741) | DYRK1A iso2 (Tyr136) | DYRK1A iso2 (Tyr312) | DYRK1A iso4 (Tyr145) |
| DYRK1A iso4 (Tyr321) | DYRK1A (Tyr145) | DYRK1A (Tyr321) | DYRK1B (Tyr273) |
| DYRK2 (Tyr382) | DYRK3 (Tyr369) | DYRK4 (Tyr264) | EGFR (Tyr1016) |
| EGFR (Tyr1069) | EGFR (Tyr1092) | EGFR (Tyr1110) | EGFR (Tyr1125) |
| EGFR (Tyr1138) | EGFR (Tyr1172) | EGFR (Tyr1197) | EGFR (Tyr727) |
| EGFR (Tyr827) | EGFR (Tyr869) | EGFR (Tyr998) | EphA1 (Tyr599) |
| EphA1 (Tyr605) | EphA1 (Tyr781) | EphA2 (Tyr575) | EphA2 (Tyr588) |
| EphA2 (Tyr589) | EphA2 (Tyr594) | EphA2 (Tyr595) | EphA2 (Tyr628) |
| EphA2 (Tyr694) | EphA2 (Tyr735) | EphA2 (Tyr772) | EphA2 (Tyr773) |
| EphA2 (Tyr921) | EphA2 (Tyr922) | EphA2 (Tyr930) | EphA2 (Tyr960) |
| EphA3 (Tyr123) | EphA3 (Tyr124) | EphA3 (Tyr596) | EphA3 (Tyr602) |
| EphA3 (Tyr736) | EphA3 (Tyr779) | EphA3 (Tyr937) | EphA4 (Tyr596) |
| EphA4 (Tyr602) | EphA4 (Tyr779) | EphA4 (Tyr798) | EphA5 (Tyr650) |
| EphA5 (Tyr656) | EphA5 (Tyr672) | EphA5 (Tyr790) | EphA5 (Tyr833) |
| EphA6 (Tyr787) | EphA6 (Tyr849) | EphA7 (Tyr608) | EphA7 (Tyr614) |
| EphA7 (Tyr791) | EphB1 (Tyr575) | EphB1 (Tyr582) | EphB1 (Tyr594) |
| EphB1 (Tyr600) | EphB1 (Tyr634) | EphB1 (Tyr778) | EphB1 (Tyr798) |
| EphB2 iso2 (Tyr596) | EphB2 iso2 (Tyr602) | EphB2 iso2 (Tyr780) | EphB2 (Tyr175) |
| EphB2 (Tyr181) | EphB2 (Tyr194) | EphB2 (Tyr577) | EphB2 (Tyr584) |
| EphB2 (Tyr585) | EphB2 (Tyr592) | EphB2 (Tyr596) | EphB2 (Tyr602) |
| EphB2 (Tyr604) | EphB2 (Tyr610) | EphB2 (Tyr780) | EphB2 (Tyr788) |
| EphB2 (Tyr912) | EphB3 (Tyr593) | EphB3 (Tyr595) | EphB3 (Tyr600) |
| EphB3 (Tyr603) | EphB3 (Tyr608) | EphB3 (Tyr609) | EphB3 (Tyr614) |
| EphB3 (Tyr754) | EphB3 (Tyr787) | EphB3 (Tyr792) | EphB3 (Tyr812) |
| EphB3 (Tyr919) | EphB3 (Tyr924) | EphB4 (Tyr574) | EphB4 (Tyr581) |
| EphB4 (Tyr590) | EphB4 (Tyr596) | EphB4 (Tyr614) | EphB4 (Tyr774) |
| EphB4 (Tyr906) | EphB4 (Tyr987) | EphB6 (Tyr628) | EphB6 (Tyr635) |
| EphB6 (Tyr637) | EphB6 (Tyr638) | EphB6 (Tyr644) | EphB6 (Tyr645) |
| EphB6 (Tyr651) | FAK iso2 (Tyr216) | FAK iso2 (Tyr226) | FAK iso2 (Tyr418) |
| FAK iso2 (Tyr424) | FAK iso2 (Tyr425) | FAK iso3 (Tyr397) | FAK iso3 (Tyr407) |
| FAK iso3 (Tyr570) | FAK iso3 (Tyr576) | FAK iso3 (Tyr577) | FAK iso3 (Tyr861) |
| FAK (Tyr397) | FAK (Tyr407) | FAK (Tyr441) | FAK (Tyr570) |
| FAK (Tyr576) | FAK (Tyr577) | FAK (Tyr608) | FAK (Tyr614) |
| FAK (Tyr615) | FAK (Tyr861) | FAK (Tyr899) | FAK (Tyr925) |
| FAK (Tyr936) | Fer (Tyr402) | Fer (Tyr714) | Fer (Tyr715) |
| Fes (Tyr156) | Fes (Tyr713) | FGFR1 (Tyr154) | FGFR1 (Tyr583) |
| FGFR1 (Tyr585) | FGFR1 (Tyr653) | FGFR1 (Tyr654) | FGFR1 (Tyr730) |
| FGFR2 (Tyr466) | FGFR2 (Tyr586) | FGFR2 (Tyr588) | FGFR2 (Tyr656) |
| FGFR2 (Tyr657) | FGFR2 (Tyr805) | FGFR2 (Tyr812) | FGFR3 (Tyr577) |
| FGFR3 (Tyr647) | FGFR3 (Tyr648) | FGFR4 iso3 (Tyr874) | FGFR4 iso3 (Tyr875) |
| FGFR4 (Tyr642) | FGFR4 (Tyr643) | Fgr (Tyr180) | Fgr (Tyr208) |
| Fgr (Tyr209) | Fgr (Tyr28) | Fgr (Tyr34) | Fgr (Tyr412) |
| Fgr (Tyr523) | FLT3 (Tyr589) | FLT3 (Tyr726) | FLT3 (Tyr842) |
| FLT3 (Tyr969) | FRK (Tyr104) | FRK (Tyr132) | FRK (Tyr221) |
| FRK (Tyr317) | FRK (Tyr368) | FRK (Tyr387) | FRK (Tyr46) |
| FRK (Tyr497) | FRK (Tyr504) | FRK (Tyr53) | FRK (Tyr99) |
| Fyn iso2 (Tyr213) | Fyn iso2 (Tyr214) | Fyn iso2 (Tyr417) | Fyn (Tyr185) |
| Fyn (Tyr213) | Fyn (Tyr214) | Fyn (Tyr28) | Fyn (Tyr339) |
| Fyn (Tyr420) | Fyn (Tyr440) | Fyn (Tyr531) | Hck (Tyr207) |
| Hck (Tyr209) | Hck (Tyr330) | Hck (Tyr409) | Hck (Tyr411) |
| Hck (Tyr51) | Hck (Tyr520) | Hck (Tyr522) | HER2 (Tyr1005) |
| HER2 (Tyr1127) | HER2 (Tyr1139) | HER2 (Tyr1248) | HER2 (Tyr735) |
| HER2 (Tyr877) | HER2 (Tyr878) | HER3 (Tyr1054) | HER3 (Tyr1156) |
| HER3 (Tyr1159) | HER3 (Tyr1197) | HER3 (Tyr1199) | HER3 (Tyr1262) |
| HER3 (Tyr1276) | HER3 (Tyr1286) | HER3 (Tyr1289) | HER3 (Tyr1307) |
| HER3 (Tyr1325) | HER3 (Tyr1328) | HER4 (Tyr1056) | HER4 (Tyr1128) |
| HER4 (Tyr1134) | HER4 (Tyr1268) | HER4 (Tyr1284) | HER4 (Tyr733) |
| IGF1R (Tyr1161) | IGF1R (Tyr1163) | IGF1R (Tyr1165) | IGF1R (Tyr1166) |
| IGF1R (Tyr1167) | IGF1R (Tyr1168) | IGF1R (Tyr1346) | IGF1R (Tyr1352) |
| IGF1R (Tyr577) | IGF1R (Tyr580) | InsR iso2 (Tyr1173) | InsR iso2 (Tyr1177) |
| InsR iso2 (Tyr1178) | InsR iso2 (Tyr1343) | InsR iso2 (Tyr1349) | InsR (Tyr1149) |
| InsR (Tyr1175) | InsR (Tyr1179) | InsR (Tyr1180) | InsR (Tyr1185) |
| InsR (Tyr1189) | InsR (Tyr1190) | InsR (Tyr1345) | InsR (Tyr1351) |
| InsR (Tyr1355) | InsR (Tyr1361) | ITK (Tyr146) | ITK (Tyr180) |
| ITK (Tyr198) | ITK (Tyr273) | ITK (Tyr40) | ITK (Tyr512) |
| JAK1 (Tyr1033) | JAK1 (Tyr1034) | JAK1 (Tyr1035) | JAK1 (Tyr220) |
| JAK2 (Tyr1007) | JAK2 (Tyr1008) | JAK2 (Tyr570) | JAK2 (Tyr790) |
| JAK2 (Tyr813) | JAK2 (Tyr931) | JAK2 (Tyr940) | JAK2 (Tyr956) |
| JAK2 (Tyr966) | JAK3 (Tyr785) | Kit (Tyr578) | Kit (Tyr703) |
| Kit (Tyr721) | Kit (Tyr730) | Kit (Tyr936) | Lck (Tyr192) |
| Lck (Tyr394) | Lck (Tyr505) | Lmr2 (Tyr1100) | Lmr2 (Tyr1448) |
| Lmr2 (Tyr1468) | Lmr3 (Tyr156) | LTK (Tyr672) | LTK (Tyr676) |
| LTK (Tyr677) | Lyn iso2 (Tyr172) | Lyn iso2 (Tyr173) | Lyn iso2 (Tyr376) |
| Lyn iso2 (Tyr487) | Lyn (Tyr117) | Lyn (Tyr193) | Lyn (Tyr194) |
| Lyn (Tyr265) | Lyn (Tyr266) | Lyn (Tyr306) | Lyn (Tyr316) |
| Lyn (Tyr32) | Lyn (Tyr397) | Lyn (Tyr460) | Lyn (Tyr473) |
| Lyn (Tyr501) | Lyn (Tyr508) | Mer (Tyr549) | Mer (Tyr744) |
| Mer (Tyr748) | Mer (Tyr749) | Mer (Tyr753) | Mer (Tyr754) |
| Mer (Tyr929) | Met (Tyr1003) | Met (Tyr1093) | Met (Tyr1228) |
| Met (Tyr1230) | Met (Tyr1232) | Met (Tyr1233) | Met (Tyr1234) |
| Met (Tyr1235) | Met (Tyr1349) | Met (Tyr1356) | Met (Tyr1365) |
| NPM-ALK (Tyr138) | NPM-ALK (Tyr152) | NPM-ALK (Tyr156) | NPM-ALK (Tyr191) |
| NPM-ALK (Tyr338) | NPM-ALK (Tyr567) | NPM-ALK (Tyr644) | NPM-ALK (Tyr646) |
| NPM-ALK (Tyr664) | PDGFRa (Tyr1018) | PDGFRa (Tyr572) | PDGFRa (Tyr574) |
| PDGFRa (Tyr613) | PDGFRa (Tyr731) | PDGFRa (Tyr742) | PDGFRa (Tyr754) |
| PDGFRa (Tyr762) | PDGFRa (Tyr768) | PDGFRa (Tyr849) | PDGFRa (Tyr944) |
| PDGFRa (Tyr958) | PDGFRa (Tyr962) | PDGFRa (Tyr988) | PDGFRb (Tyr739) |
| PDGFRb (Tyr771) | PDGFRb (Tyr778) | PIK3C2A (Tyr73) | PIK3C2B (Tyr1056) |
| PIK3C2B (Tyr127) | PIK3C2B (Tyr1541) | PIK3C2B (Tyr228) | PIK3C2B (Tyr68) |
| PIK3C2G (Tyr1437) | PIK3CA (Tyr317) | PIK3CA (Tyr508) | PIK3CB (Tyr246) |
| PIK3CB (Tyr425) | PIK3CB (Tyr503) | PIK3CB (Tyr504) | PIK3CB (Tyr505) |
| PIK3CB (Tyr772) | PIK3CB (Tyr956) | PIK3CB (Tyr962) | PIK3CD (Tyr484) |
| PIK3CD (Tyr485) | PIK3CD (Tyr524) | PIK3CD (Tyr935) | PIK3CD (Tyr936) |
| PIK3CG (Tyr757) | PIK3R1 (Tyr368) | PIK3R1 (Tyr452) | PIK3R1 (Tyr463) |
| PIK3R1 (Tyr467) | PIK3R1 (Tyr470) | PIK3R1 (Tyr508) | PIK3R1 (Tyr528) |
| PIK3R1 (Tyr556) | PIK3R1 (Tyr580) | PIK3R1 (Tyr607) | PIK3R2 (Tyr365) |
| PIK3R2 (Tyr443) | PIK3R2 (Tyr449) | PIK3R2 (Tyr453) | PIK3R2 (Tyr458) |
| PIK3R2 (Tyr461) | PIK3R2 (Tyr464) | PIK3R2 (Tyr467) | PIK3R2 (Tyr505) |
| PIK3R2 (Tyr599) | PIK3R2 (Tyr605) | PIK3R3 (Tyr195) | PIK3R3 (Tyr199) |
| PIK3R3 (Tyr202) | PIK3R3 (Tyr341) | PIK4CA iso3 (Tyr1059) | PIK4CA iso3 (Tyr1182) |
| PIK4CA iso3 (Tyr556) | PIK4CA iso3 (Tyr719) | PIK4CA (Tyr1096) | PIK4CA (Tyr1745) |
| PIK4CA (Tyr2032) | PIK4CA (Tyr470) | PIK4CA (Tyr633) | PIK4CA (Tyr973) |
| PIP5K1A iso2 (Tyr129) | PIP5K1A iso2 (Tyr333) | PIP5K1A iso2 (Tyr347) | PIP5K1A (Tyr142) |
| PIP5K1A (Tyr346) | PIP5K1A (Tyr360) | PIP5K1A (Tyr483) | PIP5K2A (Tyr246) |
| PIP5K2A (Tyr93) | PIP5K2B (Tyr167) | PIP5K2B (Tyr197) | PIP5K2B (Tyr98) |
| PIP5KG (Tyr136) | PIP5K (Tyr154) | PIP5K (Tyr1772) | PIP5K (Tyr1773) |
| PIP5K (Tyr324) | Pyk2 iso2 (Tyr579) | Pyk2 iso2 (Tyr580) | Pyk2 iso2 (Tyr777) |
| Pyk2 (Tyr402) | Pyk2 (Tyr579) | Pyk2 (Tyr580) | Pyk2 (Tyr683) |
| Pyk2 (Tyr699) | Pyk2 (Tyr722) | Pyk2 (Tyr819) | Pyk2 (Tyr849) |
| Ret (Tyr1062) | Ret (Tyr1096) | Ret (Tyr687) | Ret (Tyr900) |
| Ret (Tyr905) | Ron (Tyr1238) | Ron (Tyr1239) | Ron (Tyr1353) |
| Ron (Tyr1360) | ROR1 (Tyr160) | ROR1 (Tyr173) | ROR1 (Tyr786) |
| ROR1 (Tyr789) | ROR1 (Tyr828) | ROR1 (Tyr836) | ROR2 (Tyr666) |
| ROR2 (Tyr873) | ROS (Tyr1535) | ROS (Tyr1923) | ROS (Tyr2110) |
| ROS (Tyr2114) | ROS (Tyr2115) | ROS (Tyr2274) | ROS (Tyr2323) |
| ROS (Tyr2334) | ROS (Tyr2342) | Src (Tyr187) | Src (Tyr216) |
| Src (Tyr419) | Src (Tyr424) | Src (Tyr439) | Src (Tyr444) |
| Src (Tyr530) | Src (Tyr535) | Syk (Tyr203) | Syk (Tyr244) |
| Syk (Tyr296) | Syk (Tyr317) | Syk (Tyr323) | Syk (Tyr342) |
| Syk (Tyr346) | Syk (Tyr348) | Syk (Tyr352) | Syk (Tyr47) |
| Syk (Tyr525) | Syk (Tyr526) | Syk (Tyr568) | Syk (Tyr630) |
| Syk (Tyr631) | Syk (Tyr74) | TEC (Tyr228) | TEC (Tyr233) |
| TEC (Tyr518) | TIE2 (Tyr897) | Tnk1 (Tyr661) | TrkA iso2 (Tyr670) |
| TrkA (Tyr676) | TrkA (Tyr680) | TrkA (Tyr681) | TrkA (Tyr791) |
| TrkC iso2 (Tyr516) | TrkC iso2 (Tyr597) | TrkC iso2 (Tyr604) | TrkC (Tyr516) |
| TTK (Tyr374) | TTK (Tyr462) | TTK (Tyr833) | TTK (Tyr836) |
| Tyk2 (Tyr1054) | Tyk2 (Tyr1145) | Tyk2 (Tyr291) | Tyk2 (Tyr292) |
| Tyk2 (Tyr433) | Tyk2 (Tyr827) | Tyro3 (Tyr671) | Tyro3 (Tyr675) |
| Tyro3 (Tyr681) | Tyro3 (Tyr685) | Tyro3 (Tyr686) | Tyro3 (Tyr828) |
| VEGFR-1 (Tyr1048) | VEGFR-1 (Tyr1053) | VEGFR-1 (Tyr1213) | VEGFR-1 (Tyr1242) |
| VEGFR-1 (Tyr383) | VEGFR-1 (Tyr388) | VEGFR-1 (Tyr794) | VEGFR-2 (Tyr1054) |
| VEGFR-2 (Tyr1059) | VEGFR-2 (Tyr1214) | VEGFR-3 (Tyr1063) | VEGFR-3 (Tyr1068) |
| Yes (Tyr141) | Yes (Tyr146) | Yes (Tyr159) | Yes (Tyr194) |
| Yes (Tyr220) | Yes (Tyr221) | Yes (Tyr222) | Yes (Tyr223) |
| Yes (Tyr32) | Yes (Tyr343) | Yes (Tyr345) | Yes (Tyr424) |
| Yes (Tyr426) | Yes (Tyr444) | Yes (Tyr446) | Yes (Tyr535) |
| Yes (Tyr537) | ZAP70 (Tyr164) | ZAP70 (Tyr178) | ZAP70 (Tyr248) |
| ZAP70 (Tyr292) | ZAP70 (Tyr315) | ZAP70 (Tyr319) | ZAP70 (Tyr46) |
| ZAP70 (Tyr474) | ZAP70 (Tyr492) | ZAP70 (Tyr493) | ZAP70 (Tyr597) |
| ZAP70 (Tyr598) | ZAP70 (Tyr69) | ZAP70 (Tyr87) | |
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