Render Target: STATIC
Render Timestamp:
6/7/2026, 8:42:46 PM EDT
6/8/2026, 12:42:46 AM UTC
Commit: 33ae406c5df2bbc7a7d3c17605228fbeff8ea416
XML generation date: 2026-06-05 17:24:23.141
Product last modified at: 2025-12-21T22:58:42.790Z
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PDP - Template Name: Protein substrate
PDP - Template ID: *******8a23d84

GSK-3 Fusion Protein #9237

Inquiry Info. # 9237

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    Product Specifications

    MW (kDa) 27

    Product Information

    Product Description

    GSK-3 Fusion Protein serves as a useful substrate for assaying Akt kinase activity. It is expressed as a protein fusion to the GSK-3 α/β crosstide, corresponding to residues surrounding GSK-3 α/β (Ser21/9) (CGPKGPGRRGRRRTSSFAEG).
    MW (kDa) 27

    Storage

    Store at -20°C.

    Source / Purification

    GSK-3 Fusion Protein is expressed as a GST fusion protein in E. coli.

    Background

    Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).

    Alternate Names

    Glycogen Synthase Kinase; gsk-3α; gsk-3β; GSK3; gsk3α; gsk3β; pp110; screeningkit; substrate

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