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| 製品# | サイズ | 数量 | 価格 | 在庫 |
|---|---|---|---|---|
| 34995T | 1 Kit (6 x 20 microliters) |
|
| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| BCAT1 (D6D4K) Rabbit mAb 88785 | 20 µl |
|
H M | 43 | Rabbit IgG |
| BCAT2 (D8K3O) Rabbit mAb 79764 | 20 µl |
|
H Mk | 39 | Rabbit IgG |
| BCKDH-E1α (E4T3D) Rabbit mAb 90198 | 20 µl |
|
H M R | 49 | Rabbit IgG |
| Phospho-BCKDH-E1α (Ser293) (E2V6B) Rabbit mAb 40368 | 20 µl |
|
H M R Mk | 49 | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Rab | Goat |
製品情報
Monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues near the amino terminus of human BCAT1 protein, residues surrounding Leu39 of human BCAT2 protein, residues near the carboxy terminus of human BCKDH-E1α protein, and a synthetic phosphopeptide corresponding to residues surrounding Ser292 of mature human BCKDH-E1α protein, which corresponds to Ser293 of mature mouse BCKDH-E1α protein and Ser293 of mature rat BCKDH-E1α protein.
BCAT1 and BCAT2 are cytosolic and mitochondrial branched-chain aminotransferases, respectively (1,2). Research studies have implicated BCAT1 in distant metastasis in patients with advanced colorectal cancer (3). Disruption of BCAT2 in mice leads to higher levels of plasma branched-chain amino acids (BCAAs), reduced adiposity and body weight, and increased energy expenditure, suggesting its role in regulating insulin sensitivity (4). BCAAs leucine, isoleucine, and valine are essential amino acids in mammals, but elevated levels of BCAAs have been implicated in cardiovascular and metabolic disorders (5). The branched-chain α-keto acid dehydrogenase complex (BCKDH) catalyzes the rate-limiting step in the BCAA degradation pathway (6,7). Branched-chain α-keto acid decarboxylase (BCKDH-E1) is one of three enzymatic components in this complex (7). The α subunit of BCKDH-E1 (BCKDH-E1α) is critical for the regulation of BCKDH. Phosphorylation of BCKDH-E1α was shown to play a key role in regulating the enzymatic activity of this complex (7-9). Phosphorylation of BCKDH-E1α at Ser293 inactivates BCKDH (7,8). A significant elevation in plasma BCAA levels was reported to correlate with increased phosphorylation of BCKDH-E1α at Ser293 and suppressed BCKDH activity in the liver of diabetic mice (9).
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