Render Target: SSR
Render Timestamp: 2024-12-10T20:07:10.721Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:58:45.333
Product last modified at: 2024-11-22T15:30:10.275Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CCDC124 (E2G4Q) Rabbit mAb #79516

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 28
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CCDC124 (E2G4Q) Rabbit mAb recognizes endogenous levels of total CCDC124 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCDC124 protein.

    Background

    Translation is reversibly shut down in cells that are deprived of nutrients. In these cells, ribosomes bind to inhibitory factors and are kept inactive. After nutrient deprivation, translation recovers. CCDC124 (coiled-coil domain-containing protein 124/coiled-coil domain-containing short open reading frame 124) plays an active role in translation recovery after starvation (1). In addition, research studies show that the non-structural protein 1 (Nsp1) from SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) associates with ribosomes and shuts down host protein translation. CCDC124 is in one of the two major populations of translationally inactive ribosomes in the Nsp1-bound 80S complexes (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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