Render Target: STATIC
Render Timestamp:
6/4/2026, 7:49:41 PM EDT
6/4/2026, 11:49:41 PM UTC
Commit: 33ae406c5df2bbc7a7d3c17605228fbeff8ea416
XML generation date: 2026-03-04 16:28:15.192
Product last modified at: 2026-03-20T08:11:34.637Z
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PDP - Template Name: Antibody Duet
PDP - Template ID: *******ad0fa02

PhosphoPlus® GRB2 (Tyr160) Antibody Duet #59530

    Product Information

    Kit Usage Information

    Protocols

    Product Description

    PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from the CST product offering based on superior performance in specified applications.

    Background

    Growth factor receptor-binding protein 2 (GRB2) is an adaptor protein that is involved in RTK signal transduction. The SH2 domain of GRB2 binds to tyrosine phosphorylated proteins, such as EGFR, IRS-1, Shc, and Gab1 (1). The SH3 domain of GRB2 associates with SOS, which stimulates the Ras GTP-binding activity, leading to the activation of the MAP kinase and other signaling pathways. Phosphorylation of GRB2 at Tyr209 by Bcr-Abl and EGFR abolishes its association with SOS and negatively regulates downstream signaling (2).
    GRB2 is phosphorylated at Tyr160 by NPM-ALK kinase and Src kinase (3,4). The phosphorylation promotes its disassociation from dimer to monomer, stabilizes its association with SOS, and activates the downstream MAP kinase signaling (5).
    For Research Use Only. Not for Use in Diagnostic Procedures.
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