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| 製品# | サイズ | 数量 | 価格 | 在庫 |
|---|---|---|---|---|
| 74798T | 1 Kit (8 x 20 microliters) |
|
| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| PSD95 (D74D3) XP® Rabbit mAb 3409 | 20 µl |
|
H M R | 95 | Rabbit IgG |
| Synaptophysin (D8F6H) XP® Rabbit mAb 36406 | 20 µl |
|
H M R | 38 | Rabbit IgG |
| Bassoon (D63B6) Rabbit mAb 6897 | 20 µl |
|
M R | 420 | Rabbit IgG |
| Complexin-1/2 (D8A6E) Rabbit mAb 28070 | 20 µl |
|
H M R | 14-16 | Rabbit IgG |
| Synaptotagmin-1 (D33B7) Rabbit mAb 14558 | 20 µl |
|
H M R | 60 | Rabbit IgG |
| SHANK3 (D5K6R) Rabbit mAb 64555 | 20 µl |
|
H M R | 220 | Rabbit IgG |
| Synapsin-1 (D12G5) XP® Rabbit mAb 5297 | 20 µl |
|
H M R | 77 | Rabbit IgG |
| SynGAP (D78B11) Rabbit mAb 5540 | 20 µl |
|
M R | 140 | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Rab | Goat |
製品情報
Monoclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly299 of human Synaptophysin protein, Gln1217 of human bassoon protein, Pro125 of human complexin-2 protein, Arg400 of human synaptotagmin-1 protein, Ile1210 of human SHANK3 protein, Gln483 of human synapsin-1 protein, Arg732 of human SynGAP protein, and the amino-terminal of human PSD95 protein.
Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms (1). Synapsin-1 is a neuronal phospho-protein localized to presynaptic terminals. Synapsin-1 plays an important role in synapse formation, neurotransmitter regulation, and regulation of synaptic vesicle fusion and trafficking (2,3). Synaptotagmin-1 (SYT1) is an integral membrane protein found in synaptic vesicles thought to play a role in vesicle trafficking and exocytosis (4). Complexin isoforms 1 and 2 are small synaptic proteins that bind to SNARE complexes, responsible for regulating exocytosis and synaptic vesicle fusion (5). SynGAP is a synaptic GTPase-activating protein selectively expressed in the brain and found at higher concentrations specifically at excitatory synapses in the mammalian forebrain. SynGAP interacts with the PDZ domains of PSD95, a postsynaptic scaffolding protein that couples SynGAP to NMDA receptors (6). PSD95 is involved in the assembly and function of the postsynaptic density (PSD) complex (7,8). SHANK proteins act as scaffolds at the neuronal PSD (9), where they play a critical role in PSD assembly of excitatory synapses during development (10). Bassoon (BSN) is a scaffolding protein component of the synaptic ribbon and of the cytomatrix at the active zones of both excitatory and inhibitory synapses with a presumptive role in orchestrating events of the synaptic vesicle cycle (11-13). Together, these proteins can be used to measure presynaptic and postsynaptic proteins and synaptic development under normal and disease conditions.
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STRING - Known and Predicted Protein-Protein Interactions.
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