Resources results for "beta catenin"

Products (1433)
Resources (337)

Wnt/β-Catenin Signaling

Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.

Adhesion/ECM/Cytoskeleton

Overview of Adhesion and Extracellular Matrix signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.

Cancer Publications from CST

List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).

Contribution of Soluble Factors to EMT

A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.

Ubiquitin Ligase Table

The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).

Publications By Our Scientists

A comprehensive list of peer-reviewed publications from Cell Signaling Technology.

SimpleChIP® Plus Sonication Chromatin Immunoprecipitation Protocol (Magnetic Beads)

SimpleChIP® Plus Sonication Chromatin Immunoprecipitation Protocol (Magnetic Beads): easy to follow directions describing the step by step experimental procedure

Adherens Junction Dynamics

Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.

Based on homology, our β-Tubulin Antibody #2146, β-Tubulin (9F3) Rabbit mAb #2128, β-Tubulin (D3U1W) Mouse mAb #86298, and β-Tubulin (D2N5G) Rabbit mAb #15115 should detect β-Tubulin isoforms A, B, and C. The antigen sequences for these antibodies have 96% homology with beta 2C, beta 4B, beta 5B, and beta 4A isoforms 1, 2, and 3, and 95% homology with beta 2C isoforms A and B. Therefore they are likely to detect these subtypes.

Amyloid Beta: Amyloid Precursor Protein (APP)

Amyloid beta is a protein fragment of the amyloid precursor protein, and is the major component of Alzheimer’s disease plaques.

Mechanisms of Fibrosis

Expert-reviewed diagram providing a current overview of the Mechanisms of Fibrosis pathway with references to its role in adhesion

Acquiring Senescence

Cellular senescence is characterized by irreversible cell-cycle arrest in combination with a distinct secretory phenotype and expanded lysosomes in response to stress. Senescent cells accumulate in tissues during aging, and various markers of senescence

Resources

We have several antibodies for β-actin that are validated for IHC-P in mouse samples. These are β-Actin (13E5) Rabbit mAb #4970 and β-Actin (8H10D10) Mouse mAb #3700. We would recommend β-Actin (13E5) Rabbit mAb #4970, as β-Actin (8H10D10) Mouse mAb #3700 could be problematic due to mouse on mouse (MOM) background staining.

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From our testing, we have seen that our Glucocorticoid Receptor (D6H2L) XP® Rabbit mAb #12041 detects both the alpha and beta isoforms of the Glucocorticoid Receptor. It is possible that #12041 may detect other less common isoforms as well, but we have not confirmed this experimentally. Additionally, each of the isoforms that can be detected most likely have post-translational modifications that affect the molecular weight.

Our Glucocorticoid Receptor (D8H2) XP® Rabbit mAb #3660 detects both the alpha and beta isoforms of the Glucocorticoid Receptor. However, based on sequence alignment (and unlike #12041) #3660 is predicted to cross-react with all known alternative translation start site generated isoforms of glucocorticoid receptor-α and glucocorticoid receptor-β (80 kDa).

Please refer to Uniprot ID: P04150 for the reference sequences of both alpha and beta isoforms of the Glucocorticoid Receptor.

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Unfortunately, we are not aware if any of our amyloid-beta antibodies will detect the alpha-oligomer of the amyloid-beta protein.

Missing Link: Why Do Insulin-producing Cells in Type 2 Diabetes Fail to Divide?

A journal club article elucidating the mechanisms of beta cell failure leading to type 2 diabetes.

Protein Folding and Aggregation

We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.

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We believe the 48 kDa band may represent a heterodimer of β-crystallin B1 based on the following references:
https://www.ncbi.nlm.nih.gov/gene/1414
Dolinska MB, Sergeev YV, Chan MP, Palmer I, Wingfield PT. N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. Biochemistry. 2009 Oct 13;48(40):9684-95
Wang KJ, Wang S, Cao NQ, Yan YB, Zhu SQ. A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg mutation destabilizes the βB1/βA3-crystallin heteromer but not the βB1-crystallin homomer. Hum Mutat. 2011 Mar;32(3):E2050-60

Resources

We have several antibodies for β-actin that are validated for IHC-P in human samples. These are β-Actin (13E5) Rabbit mAb #4970 and β-Actin (8H10D10) Mouse mAb #3700. Both work well and there is no preference for this application.

Resources

Our Pan-Calcineurin A Antibody #2614 detects endogenous levels of the alpha isoform of Calcineurin A, however it may also recognize the beta and gamma isoforms. Regrettably, because it has been difficult to find suitable models, we have not specifically tested if this product will detect the beta and gamma isoforms. However, the antigenic peptide shares around 90% sequence identity with the beta isoform and around 80% sequence identity with the gamma isoform. Therefore, it is possible that there is cross-reactivity. This antibody does not cross-react with protein phosphatase 1 or 2A.

Neuroinflammation

Neuroinflammation is a condition observed in the central nervous system (CNS) in response to infection, toxic metabolites, traumatic injury, or autoimmunity.

Pathways and Diagrams by Disease Area

Find Pathways and Diagrams By Disease Area

Fibrosis

Products and Related Resources for Fibrosis SARS-CoV-2 Research

ADF Protein Domain

A scientific resource for the ADF protein domain containing information on structure, function, and binding to monomeric and filamentous actin.

Resources

It is not uncommon to see a doublet with our beta-Actin antibodies depending on the samples being tested. It is likely caused either by phosphorylation of beta-Actin on its many phosphorylation sites, resulting in a shift in size, or by cross-reactivity with gamma-Actin (beta-Actin = 375 amino acids, gamma-Actin (cytoplasmic form) = 333 amino acids).

Western Blotting Troubleshooting Guide

Western Blotting troubleshooting guide for easy to solve high and low background issues.

Developmental Biology Signaling

Overview of stem cell markers, lineage markers, development and differentiation signaling networks at Cell Signaling Technology.

Resources

Our Phospho-Acetyl-CoA Carboxylase (Ser79) (D7D11) Rabbit mAbs #11818 and #42801 detect both phospho-ACC-alpha and phospho-ACC-beta. These antibodies recognize ACC-alpha only when phosphorylated at Ser80 in human, which corresponds to Ser79 in mouse and rat. They also recognize ACC-beta only when phosphorylated at Ser222 in human, corresponding to Ser212 in mouse and Ser218 in rat.

TGF-β Signaling

Discover the TGF Beta signaling pathway and impact on cell growth & tissue homeostasis. Learn here the mechanisms behind this vital signaling cascade.

Cell Process: What role does senescence play in disease?

Senescence has been linked to a general decline in tissue function during aging as well as a number of disease states.