|Brg1 (D1Q7F) Rabbit mAb 49360
|H M R Mk
|BRD9 (E9R2I) Rabbit mAb 58906
|GLTSCR1 (E6I3A) Rabbit mAb 45441
|GLTSCR1L (E9K6F) Rabbit mAb 92805
|H M R Mk
|Anti-rabbit IgG, HRP-linked Antibody 7074
Monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues surrounding Pro576 of human BRD9 protein, Pro1545 of human GLTSCR1 protein, recombinant protein specific to the amino terminus of human Brg1 protein and human GLTSCR1L protein.
ATP-dependent chromatin remodeling complexes play an essential role in the regulation of various nuclear processes, such as gene expression, DNA replication, and repair (1,2). The SWI/SNF chromatin remodeling complex consists of more than 10 subunits with a single molecule of the ATPase catalytic subunit BRM or BRG1, but not both. The activities of these two subunits drive the disruption of histone-DNA contacts that lead to changes in accessibility of crucial regulatory elements within chromatin (2-5). The BRM/BRG1 containing SWI/SNF complexes are recruited to target promoters by transcription factors, such as nuclear receptors, p53, RB, and BRCA1, to regulate gene activation, cell growth, the cell cycle, and differentiation processes (1,6-9).
GLTSCR1 and its paralog GLTSCR1L, along with BRD9, have been identified as unique subunits of the non-canonical BAF (ncBAF) or GBAF complex. This complex contains either GLTSCR1 or GLTSCR1L instead of an ARID subunit, while also lacking the BAF45, BAF47, and BAF57 subunits. GBAF maps to regions distinct from the PBAF and canonical BAF complexes and has also been shown to be a synthetic lethal target for BAF driven cancers such as synovial sarcomas and rhabdoid tumors (10-12).
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