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cytokines

Cytokines & Growth Factors

All cytokines and growth factors listed below are produced in-house, ensuring the highest standards of quality and consistency.

  • Most products are free of tags or additional amino acids, and many are produced in mammalian cells to maximize natural conformation and glycosylation – especially important for successful in vivo applications.
  • Validation includes the use of CST antibodies to assess downstream signaling events.
 

Cytokine Receptor Complexes and Activation

3D animated video tutorial illustrating IL-6 eceptor complex formation and activation.

Jak and Cytokine Receptor Mutants in Cancer Table (Table Resources)

Jak and cytokine receptor mutations found in various cancers, along with the corresponding PubMed reference(s).

Jak/Stat Utilization Table (Table Resources)

The Jak/Stat Utilization Table displays the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.

Angiogenesis Resources (Pathway Diagram)

Overview of Angiogenesis antibodies & related reagents, interactive pathway diagrams, and other technical resources.

Immunology Signaling Pathways Poster (???content.contentType.Posters???)

CST Immunology Signaling Pathways poster includes Jak/Stat, NF-KB, Toll-like Receptor, B Cell Receptor, and T Cell Receptor signaling pathways.

Types of ELISA (Enzyme-linked Immunosorbent Assay) Tests

Several types of ELISAs have been developed: direct ELISA, indirect ELISA, sandwich ELISA, competitive ELISA, multiplex ELISA. The types of ELISAs are categorized based on the type of antibodies and enzymes used to bind the antigen of interest.

Overview of Metabolism and Metabolic Disorders

Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.

TIR Protein Domain (Protein Domains)

A scientific resource for the TIR protein domain containing information on structure, function, and binding in TLR Signaling.

Neuroinflammation in Neurodegenerative Diseases

Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer's disease, Parkinson's

Immuno-Parallel Reaction Monitoring (iPRM) (Proteomics Overviews)

iPRM is a multiplexed LC/MS assay service that combines the specificity of mass spectrometry, the throughput of an immunoassay, and the power of multiplexing to accelerate the time-to-market of your drug and/or diagnostic test.

Understanding Neurodegenerative (NDG) Diseases

Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.

Ubiquitin Ligase Table (Table Resources)

The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).

Cellular Senescence

Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.

Synopsis of Cell Proliferation, Metabolic Status, and Cell Death

Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.

Kinase-Disease Associations (Table Resources)

Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.

PI3K / Akt Signaling Resources (Pathway Diagram)

Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.

Product Shelf-Life (Product Shelflife Table)

A table that lists shelf-life expectations for CST products (when stored under the recommended conditions).

MAP Kinase Signaling Resources (Pathway Diagram)

Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.

Immunology and Inflammation (Pathway Diagram)

Expert-reviewed interactive pathways providing current overviews of NF-kB and Toll-like Receptor (TLR) signaling, as well as links to products from Cell Signaling Technology.

Nuclear Receptors (Pathway Diagram)

Expert-reviewed interactive pathway providing a current overview of Nuclear Receptor Signaling, a pathway description, select PubMed references, and links to PhosphoSitePlus.

Control Treatments by Target (Control Table)

A list of recommended cell types and treatments to be used as positive and negative controls for activation state specific antibodies

Tutorials & Application Guides

Video tutorials illustrate the science behind cellular processes and signaling pathways.

Protein and Pathway Abbreviations (Table Resources)

Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.

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