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Overview of the Immune System

Introduction

CST supports your immunology research with the highest quality antibodies. Immunology-based research focuses on the components of the human immune system and the possibility of their use to combat various diseases.

You need tools to identify and analyze immune cells and immune signaling to advance your research. CST is proud to produce top of the line antibodies for investigating proteins within the complex signaling pathways of the immune system and to contribute to the international movement to develop better, more efficacious therapeutics.

The immune system is comprised of two broad cellular responses:

  • Innate immunity
  • Adaptive immunity

Innate Immunity

The innate immune response is your first line of defense against pathogens. It provides a quick response to pathogens by many mechanisms, including cytokine production and complement activation.

The cell types involved in the innate immune response are phagocytic cells: neutrophils, macrophages, natural killer cells, basophils, and others.

As a leader in antibody development, CST has developed a wide array of highly effective antibodies against proteins involved in innate immunity such as the STING, NFƘB, and inflammasome signaling pathways.

IL-1 12242 colitis colon

IL-1β (3A6) Mouse mAb #12242: IHC analysis of paraffin-embedded human large intestine (chronic colitis of the colon) #12242.

IRF-3 10949 human colon carcinoma

IRF-3 (D9J5Q) Mouse mAb #10949: IHC analysis of paraffin-embedded human colon carcinoma using #10949.

IRF-3 10949 non Hodgkins lymphoma

IRF-3 (D9J5Q) Mouse mAb #10949: IHC analysis of paraffin-embedded human non-Hodgkin’s lymphoma using #10949.

IRF-3 10949 ovary194 human endometrioid adenocarcinoma

IRF-3 (D9J5Q) Mouse mAb #10949: IHC analysis of paraffin-embedded ovary194 human endometrioid adenocarcinoma using #10949.

IRF-3 10949 ovary202 human clear cell adenocarcinoma

IRF-3 (D9J5Q) Mouse mAb #10949: IHC analysis of paraffin-embedded ovary202 human clear cell adenocarcinoma of the ovary using #10949.

Adaptive Immunity

The adaptive immune response uses antigen-specific receptors to detect foreign antigens. This is a slow occurrence that results from efforts of T Cells, B cells, and natural killer T Cells. Humoral immunity uses antibodies for detection, whereas cell-mediated immunity uses T Cells to destroy the affected cells.

When the antigen is encountered for the first time, lymphocytes exert the primary immune response. The same cells can “learn” from their experience, so that a subsequent encounter with the same antigen will result in a quicker, secondary immune response.

CST has developed a wide array of highly effective antibodies to label the many proteins involved in the lymphocyte signaling pathways, including the TCR and BCR.

CD3 85061 mouse colon

CD3ε (D7A6E™) XP® Rabbit mAb #85061: IHC analysis of paraffin-embedded human tonsil using #85061.

CD4 25229 mouse lung tumor

CD4 (D7D2Z) Rabbit mAb #25229: IHC analysis of paraffin-embedded mouse colon using #25229.

CD8 98941 mouse small intestine

CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific) #98941: IHC analysis of paraffin-embedded mouse small intestine using #98941.

Immune Cell Signaling

The regulation of immune cells occurs through a number of key signaling pathways. Each pathway is comprised of a complex network of proteins that interact with one another to induce a specific cellular response to stimuli.

In addition to the STING, NFƘB, inflammasome, TCR, and BCR signaling pathways, the JAK/STAT and TLR signaling pathways also play major roles in immune cell signaling.

Syk 13198 human lymph node

Syk (D3Z1E) XP® Rabbit mAb #13198: IHC analysis of paraffin-embedded human lymph node using #13198.

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