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| Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
|---|---|---|---|---|---|
| AHCYL1/IRBIT (D3A5G) Rabbit mAb 94248 | 20 µl |
|
H M R Mk | 61 | Rabbit IgG |
| CBS (D8F2P) Rabbit mAb 14782 | 20 µl |
|
H M R | 61 | Rabbit IgG |
| Cystathionine γ-Lyase (D1N1D) Rabbit mAb 19689 | 20 µl |
|
H M R | 44 | Rabbit IgG |
| MTHFR (D1E4V) Rabbit mAb 25164 | 20 µl |
|
H | 78 | Rabbit IgG |
| MTHFD1L (D8T7L) Rabbit mAb 14999 | 20 µl |
|
H M | 106 | Rabbit IgG |
| MTHFD2 (D8W9U) Rabbit mAb 41377 | 20 µl |
|
H | 35 | Rabbit IgG |
| SHMT1 (D3B3J) Rabbit mAb 80715 | 20 µl |
|
H M R Mk | 50 | Rabbit IgG |
| Thymidylate Synthase (D5B3) XP® Rabbit mAb 9045 | 20 µl |
|
H M R Mk | 30 | Rabbit |
| Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Rab | Goat |
製品情報
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu50 of human AHCYL1/IRBIT protein, Leu220 of human CBS protein, Pro298 of human cystathionine γ-lyase protein, Pro39 of human MTHFR protein, Ala264 of human MTHFD1L protein, Leu340 of human MTHFD2 protein, Glu187 of human SHMT1 protein, and residues near the carboxy terminus of human thymidylate synthase protein.
One-carbon metabolism includes various enzymatic reactions involving the transfer of one-carbon groups mediated by folate cofactor (1). The activated one-carbon groups are used by various metabolic pathways, including purine synthesis, thymidine synthesis, and remethylation of homocysteine to methionine (1). S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) is a member of the S-adenosylhomocysteine hydrolase family, which participates in the metabolism of S-adenosyl-L-homocysteine (2). Cystathionine beta-synthase (CBS) is a key enzyme involved in sulfur amino acid metabolism as it catalyzes the formation of cystathionine from serine and homocysteine (3,4). Cystathionine γ-lyase (CGL) is an enzyme in the transsulfuration pathway, a route in the metabolism of sulfur-containing amino acids (5). Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in one-carbon metabolism, catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (1). 5-methyltetrahydrofolate donates its methyl group for remethylation of homocysteine to methionine (1). Methionine is further converted to S-adenosylmethionine (SAM), a major reactive methyl carrier (1). NADP+ dependent methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) is a mitochondrial enzyme that catalyzes the production of formate from 10-formyl-tetrahydrofolate in one-carbon flow from mitochondria to cytoplasm (6,7). MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase involved in mitochondrial folate metabolism (8). Serine hydroxymethyltransferase 1 (SHMT1) is a cytoplasmic serine hydroxylmethyltransferase (9,10). It catalyzes the conversion of serine to glycine with the transfer of β-carbon from serine to tetrahydrofolate (THF) to form 5, 10-methylene-THF (9, 10). The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) is an essential step in the formation of thymine nucleotides, a process catalyzed by thymidylate synthase (TS or TYMS) (11-13).
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