|Androgen Receptor (E3S4N) Rabbit mAb (Carboxy-terminal Antigen) 70317||20 µl||
|Androgen Receptor (D6F11) XP® Rabbit mAb 5153||20 µl||
|Androgen Receptor (AR-V7 Specific) (E3O8L) Rabbit mAb 19672||20 µl||
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibodies are produced by immunizing rabbits with recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein, and with synthetic peptides corresponding to residues surrounding Val662 of human androgen receptor protein and Leu639 of human androgen receptor (V7 isoform) protein.
Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).
The AR3 or AR-V7 isoform, which lacks the typical ligand binding domain, is created through the alternative splicing of cryptic exons (4-5). AR-V7 is frequently expressed in castration-resistant prostate cancer (CRPC) and while dependent on the activity of the full-length androgen receptor (AR-FL), AR-V7 can activate a completely distinct transcriptional program (6-8). While enzalutamide and abiraterone have been beneficial in treating CRPC through the ligand binding domain of AR-FL, resistance in patients has been shown to be associated with AR-V7 detection in circulating tumor cells (9-12). Studies probing into mechanisms of overcoming this resistance are currently being explored and may help in stratifying patient populations for more personalized therapies (13-15).
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