|Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb 2478||20 µl||
||H M||230||Rabbit IgG|
|Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb 4060||20 µl||
||H M R Hm Mk Dm Z B||60||Rabbit IgG|
|Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb 6943||20 µl||
||H M R Mk||60||Rabbit IgG|
|Phospho-FAK (Tyr397) (D20B1) Rabbit mAb 8556||20 µl||
|Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP® Rabbit mAb 4511||20 µl||
||H M R Mk Mi Pg Sc||43||Rabbit IgG|
|Phospho-PLCγ1 (Ser1248) (D25A9) Rabbit mAb 8713||20 µl||
||H M Mk||150||Rabbit IgG|
|Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb 4370||20 µl||
||H M R Hm Mk Mi Dm Z B Dg Pg Sc||44, 42||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Rabbit monoclonal antibodies are produced by immunizing animals with synthetic phosphopeptides corresponding to residues surrounding Ser473 of human Akt protein, Tyr397 of human FAK protein, Thr180/Tyr182 of human p38 MAPK protein, Thr202/Tyr204 of human p44 MAPK protein, Ser1248 of human PLCγ1 protein, Tyr416 of human Src protein, and Tyr1175 of human VEGFR2 protein.
Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Signaling from VEGFR2 is necessary for angiogenesis in vivo (2-4). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (5). Phosphorylation of VEGFR2 at Tyr1212 provides a docking site for GRB2 binding and phosphorylation at Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ (1,5,6). Activation of VEGFR2 during angiogenesis leads to signaling through multiple downstream kinase pathways including Akt, Src, FAK, p38, and Erk1/2 (2,7).
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