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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a

Oncogene and Tumor Suppressor Antibody Sampler Kit #8678

Inquiry Info. # 8678

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    Product Information

    Product Description

    The Oncogenes and Tumor Suppressor Antibody Sampler Kit offers an economical means of investigating proteins commonly involved in the biological pathways behind oncogenesis, tumor metastasis, and cancer pathology. The kit contains enough primary and secondary antibody to perform four western blot experiments with each antibody.

    Background

    Oncogenesis is a multistep process leading to sequential alterations in several oncogenes, tumor-suppressor genes, and microRNA genes (1,2). These alterations often disrupt the expression, function, and/or activity of proteins regulating cell growth and programmed cell death. Many of the molecular mechanisms and biological pathways driving oncogenesis and cancer pathology have been identified. The signal transduction pathways regulating apoptosis, cell-cycle progression, cell adhesion, cell migration, and DNA damage responses are often disrupted. HER2/ErbB2 (3), E-Cadherin (4), p53 (5,6), Stathmin (7), BRCA1 (8,9), Akt (10), PTEN (11), and Estrogen Receptor α (12) function in many of these pathways.

    Alternate Names

    akt; brca1; Breast Cancer; cadherin; Cancer; erbb2; estrogen; her2; Malignancy; Malignant; Metastasis; Metastatic; Oncongene; p53; pten; Tumor; Tumor Suppressor

    For Research Use Only. Not for Use in Diagnostic Procedures.
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